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Congressional Testimony

Congressional Budget

FY2003 Congressional Budget Justification

FY2001 Congressional Budget Justification

FY2002 Congressional Budget Justification

FY 2011 Congressional Budget Justification

FY 2010 Congressional Budget Justification

FY 2012 Congressional Budget Justification

FY 2013 Congressional Budget Justification

Congressional Testimony

Intervening with High-Risk College Students-Alcohol Dependency Scale

FY 2000 President's Budget Request for NIAAA - Director's Statement Before the House Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies

Tumor Necrosis Factor-a (TNFa) in Alcohol-induced Liver Injury

Neuropeptide Y (NPY) and Alcohol Consumption

NIAAA Director's Statement before the House Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies, March 19, 1998

FY 2005 President's Budget Request for NIAAA - Director's Statement Before the House and Senate Appropriations Subcommittees

FY 2008 President's Budget Request for NIAAA - Director's Statement Before the Senate Subcommittee on Labor-HHS Appropriations

X-ray Structure of Aldehyde Dehydrogenase (Chart 3)

Relative Timeframes for Various Types of Alcohol Research to Yield Practical Applications (Chart 2)

FY 2010 President's Budget Request for NIAAA - Acting Director's Statement before the Senate Subcommittee on Labor-HHS-Education Appropriations, May 21, 2009

Prevalence of Lifetime Alcohol Dependance by Age at Onset of Drinking (Chart 1)

FY 2001 President's Budget Request for NIAAA - Director's Statement Before the House and Senate Appropriations Subcommittees

Low Doses of Alcohol Impair Merchant Ship Pilots (simulated)

FY 2003 President's Budget Request for NIAAA - Acting Director's Statement Before the House and Senate Appropriations Subcommittees

Genes-Behavior Link

Locating Alcohol's Action

NIAAA Director's Statement Before the House Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies

FY 2002 President's Budget Request for NIAAA - Director's Statement Before the House and Senate Appropriations Subcommittees

FY 1999 President's Budget Request for NIAAA - Director's Statement Before the House Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies

FY 2005 Hearing on Substance Abuse and Mental Health - Director's Statement Before the House Appropriations Subcommittee

NIAAA Director's Statement before the House Committee on Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies, March 4, 1997

FY 2009 President's Budget Request for NIAAA - Director's Statement before the House Subcommittee on Labor-HHS Appropriations, March 5, 2008

FY 2004 President's Budget Request for NIAAA - Director's Statement Before the Senate Subcommittee on Labor-HHS-Education Appropriations

NIAAA outreach activities

FY 2008 President's Budget Request for NIAAA - Director's Statement Before the House Subcommittee on Labor-HHS Appropriations

A Medical Education Model for Prevention and Treatment of Alcohol Use Disorders

Alcohol Damages the Cerebellum (image)

FY 2006 Hearing on Substance Abuse and Mental Health - Deputy Director's Statement Before the House Subcommittee on Labor-HHS-Education Appropriations

FY 2006 President's Budget Request for NIAAA - Director's Statement Before the House and Senate Appropriations Subcommittees

Significant Items In House And Senate

Advisory Council

Council Minutes

National Advisory Council Meeting-September 20-21, 2006

National Advisory Council Meeting-February 7-8, 2007

National Advisory Council Meeting - September 17-18, 2008

National Advisory Council Meeting - February 4-5, 2009

National Advisory Council Meeting - February 6-7, 2008

National Advisory Council Meeting-May 24, 2007

National Advisory Council Meeting - February 3-4, 2010

National Advisory Council Meeting - September 16-17, 2009

National Advisory Council Meeting-September 14-15, 2005

National Advisory Council Meeting - June 10-11, 2009

National Advisory Council Meeting - June 4-5, 2008

National Advisory Council Meeting - June 9-10, 2010

National Advisory Council Meeting-September 19-20, 2007

National Advisory Council Meeting-June 7-8, 2000

National Advisory Council Meeting-February 2-3, 2005

National Advisory Council Meeting-February 6-7, 2002

National Advisory Council Meeting-June 5-6, 2002

National Advisory Council Meeting-June 6-7, 2001

National Advisory Council Meeting-February 9-10, 2000

National Advisory Council Meeting-April 3, 2002

National Advisory Council Meeting-February 7-8, 2001

National Advisory Council Meeting-September 13-14, 2000

National Advisory Council Meeting-June 4-5, 2003

National Advisory Council Meeting-February 5-6, 2003

National Advisory Council Meeting-September 18-19, 2002

National Advisory Council Meeting-February 4-5, 2004

National Advisory Council Meeting-May 26-27, 2004

National Advisory Council Meeting-September 20, 2001

National Advisory Council Meeting-May 25-26, 2005

National Advisory Council Meeting-September 8-9, 2004

National Advisory Council Meeting - September 22-23, 2010

National Advisory Council Meeting - February 16-17, 2011

National Advisory Council Meeting - June 8-9, 2011

First Joint Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism and the National Advisory Council on Drug Abuse - September 12, 2011

National Advisory Council Meeting - September 12-13, 2011

Director's Reports

NIAAA Director's Report on Institute Activities to the 111th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - February 2, 2006

Director's Report on Institute Activities to 116th Meeting of Advisory Council-September 20, 2007

NIAAA Director's Report on Institute Activities to the 121st Meeting of the National Advisory Council on Alcohol Abuse and Alcoholim - June 11, 2009

Fiscal Year 2006 President's Budget Request

NIAAA Directors's Report on Institute Activities to the 120th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - February 4, 2009

NIAAA Director’s Report on Institute Activities to 117th Meeting of the National Advisory Council-February 7, 2008

Director's Report on Institute Activities to the 114th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - February 8, 2007

Director's Report on Institute Activities to the 115th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism-May 24, 2007

NIAAA Director's Report on Institute Activities to the 122nd Meeting of the National Adviosry Council on alcohol Abuse and Alcoholism - September 17, 2009

NIAAA Director's Report on Institute Activities to the 123rd Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - February 4, 2010

NIAAA Director's Report on Institute Activities to 118th Advisory Council Meeting - June 5, 2008

Director's Report on Institute Activities to the 112th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - June 8, 2006

Director's Report on Institute Activities to the 113th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - September 21, 2006

NIAAA Director's Report on Institute Activities to the 110th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - September 15, 2005

NIAAA Director's Report on Institute Activities to the 125th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - September 23, 2010

NIAAA Director's Report on Institute Activities to the 124th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - June 10, 2010

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - September 14, 2000

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - September 19, 2002

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - September 18, 2003

NIAAA Director's Report on Institute Activitites to the National Advisory Council on Alcohol Abuse and Alcoholism - September 20, 2001

NIAAA Director's Report on Institute Activities to the Naitonal Advisory Council on Alcohol Abuse and Alcoholism - February 10, 2000

NIAAA Acting Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - June 6, 2002

NIAAA Director's Report on Institutes Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - February 5, 2004

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - September 9, 2004

NIAAA Director's Report on Institute Activities to 119th Natoinal Advisory Council Meeting - September 18, 2008

NIAAA Acting Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - February 7, 2002

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - June 8, 2000

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - May 27, 2004

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - February 6, 2003

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - February 8, 2001

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - June 7, 2001

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - May 26, 2005

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - February 3, 2005

NIAAA Director's Report on Institute Activities to the National Advisory Council on Alcohol Abuse and Alcoholism - June 5, 2003

NIAAA Director's Report on Institute Activities to the 126th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - February 17, 2011

NIAAA Director's Report on Institute Activities to the 127th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - June 9, 2011

NIAAA Director's Report on Institute Activities to the 128th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - September 13, 2011

NIAAA Director's Report on Institute Activities to the 129th Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism - February 9, 2012

National Advisory Council on Alcohol Abuse and Alcoholism Roster

Organizational Information

Health Disparities Research

Vision Statement

NIAAA Celebrates 40 Years of Research, Outreach

Research Initiatives

NIAAA Mission Statement

NIAAA Organization Chart

NIAAA Organization Chart Description

Plan to Address Health Disparities Initiatives - Introduction 2005

Plan to Address Health Disparities Initiatives - 2005

Staff Directory

Strategic Plan

NIAAA Sponsored Programs

Key Facts & Stats

Facts About Alcohol and Adolescent Health

Research Findings on Underage Drinking and the Minimum Legal Drinking Age

Research Findings on College Drinking and the Minimum Legal Drinking Age

Statistical Snapshot of Underage Drinking

Minimum Legal Drinking Age (MLDA) Fact Sheets

Underage Drinking Research Initiative

Statistical Snapshot of College Drinking

News and Events

News Releases and Advisories

Neuroimaging Identifies Brain Regions Possibly Involved in Alcohol Craving

NIAAA and NOFAS Launch Awareness Campaign in District of Columbia: "Play it safe. Alcohol and pregnancy don't mix."

NIAAA-Led Study Verifies Environment-Dependent Behavioral Variation in Genetically Identical Mice

Alcohol Researchers Prove Success with Primary Care Interventions

Alcohol Researchers Localize Brain Region That Anticipates Reward

Gene Therapy Technique Reduces Alcohol Consumption in Rats

NIAAA Releases New Alcohol Prevention Website for Middle Schoolers

Faye Calhoun Named NIAAA Deputy Director

National Survey Sharpens Picture of Major Depression Among U.S. Adults

5th National Screening Day to Focus Americans on Alcohol and Health: NIAAA Analysis Suggests One-Third of Adults Are "Risky" Drinkers

Mouse Study Identifies Protective Mechanism Against Alcohol-Induced Embryo Toxicity

Mark Goldman Named NIAAA Associate Director

NIAAA Steps Up Search for Brain Mechanisms of Alcohol Abuse, Alcoholism

Dr. Markus Heilig Named NIAAA Clinical Director

Long-Chain Alcohol Found To Block Mechanism of Fetal Alcohol Syndrome

Ninth Special Report on Alcohol and Health Marks Research Gains

Researchers Shed Light on Mechanisms of Voluntary Alcohol Consumption

Research and Policy Experts Meet to Address Underage Drinking

NIAAA Researchers Estimate Alcohol and Drug Use, Abuse, and Dependence Among Welfare Recipients

NIAAA Issues New Clinician's Guide for Helping Patients Who Drink Too Much

Surgeon General Calls on Americans to Face Facts About Drinking Transportation Safety Leaders Join Alcohol Research , Prevention, and Treatment Leaders to Recommend Screenings on April 8, National Alcohol Screening Day

Community Prevention Trial Reduces Risky Drinking, Alcohol-Related Crashes and Trauma -- Environmental strategies, plus public education and awareness prove effective

Study Finds Reduced Brain Growth in Alcoholics with Family Drinking History

Largest Ever Comorbidity Study Reports Prevalence and Co-Occurrence of Alcohol, Drug, Mood and Anxiety Disorders

Kenneth Warren Named NIAAA Deputy Director

Researchers Discover Alcohol-Sensitive Membrane Channel - Site found while examining ethanol's effect on potassium channels

Ting-Kai Li, M.D. Named New Director of NIH’s Alcohol Research Institute

New Research Study in JAMA Shows Adult Marijuana Abuse and Dependence Increased During 1990s

Dr. Mark Willenbring Joins NIAAA

Parents' Escape Drinking Evokes Children's Negative Response to Alcohol Smell

NIAAA Seeks Knowledge of Alcohol and HIV/AIDS Interactions

Alcohol Researchers Prove "Saving Lives" Strategy Effective

Alcohol Researchers Confirm Molecular Culprit of Alcohol-Induced Liver Damage

Alcohol Researchers Suggest Specific Binding Site for Anesthetics and Alcohols

National Alcohol Screening Day (April 6) A National Wake-up Call - APRIL 4 Media Briefing To Kick Off Event

Stress Hormone Linked to Increased Alcohol Consumption in Animal Model

Statement of NIAAA Director Enoch Gordis, M.D.

Frequency of Light-to-Moderate Drinking Reduces Heart Disease Risk in Men

Alcohol Researchers Identify New Medication That Lessens Relapse Risk

NIAAA Names 2002 Senator Harold Hughes Memorial Award Winner

One in Four Children Exposed to Family Alcohol Abuse or Alcoholism

Surgeon General Helps To Launch First-Ever National Alcohol Screening Day

Study Links Diet Quality with Alcohol Drinking Patterns

National Institute on Alcohol Abuse and Alcoholism Launches National Initiative to Prevent Underage Drinking - Governors' Spouses Form Leadership to Keep Children Alcohol Free

NIAAA Reports Project MATCH Main Findings

NIAAA/VA Researchers Identify Possible Site of Alcohol Damage

NIAAA Names 2001 Harold Hughes Award Winner

Ralph Hingson Joins NIAAA

Alcohol Researchers Prove Brief Intervention Successful In Older Problem Drinkers

COGA Genome Scan Suggests Linkage on Chromosomes 1, 2, 4, and 7

Upcoming Events

Spring 2008 Symposia Series: Getting at Why People Change, February 27, 2008-Agenda

About the Honoree Dr. John Krystal

National Advisory Council on Alcohol Abuse and Alcoholism - February 4-5, 2009

About Jack Harold Mendelson

National Advisory Council on Alcohol Abuse and Alcoholism - September 17-18, 2008 - Agenda

Registration

National Advisory Council on Alcohol Abuse and Alcoholism - June 9-10, 2010

14th Annual Mark Keller Lecture - About the Honoree - Joannes (Jan) B. Hoek, Ph.D.

About Jack Mendelson

13th Annual Mark Keller Lecture - About the Honoree - Kathleen A. Grant, Ph.D.

Program and Contacts

Agenda

15th Annual Mark Keller Lecture Program - October 26, 2010

National Advisory Council on Alcohol Abuse and Alcoholism - September 16-17, 2009

13th Annual Mark Keller Lecture-Parking at NIH

National Advisory Council on Alcohol Abuse and Alcoholism - February 6-7, 2008

National Advisory Council on Alcohol Abuse and Alcoholism - June 10-11, 2009

Tentative Agenda

Contact

13th Annual Mark Keller Lecture Program - October 21, 2008

NIAAA 40th Anniversary Symposium – October 4, 2010

Registration

About the Honoree Dr. Marc Schuckit

National Advisory Council on Alcohol Abuse and Alcoholism - June 4-5, 2008 - Agenda

National Advisory Council on Alcohol Abuse and Alcoholism - September 22-23, 2010

Interagency Coordinating Committee on FAS May 15, 2008 Meeting-Agenda

event

15th Annual Mark Keller Lecture - About the Honoree - R. Adron Harris, Ph.D.

Agenda

About the Honoree-Dr. Anna Mae Diehl

First Joint Meeting of the National Advisory Council on Alcohol Abuse and Alcoholism and the National Advisory Council on Drug Abuse - April 11, 2011

National Advisory Council on Alcohol Abuse and Alcoholism - June 8-9, 2011

National Advisory Council on Alcohol Abuse and Alcoholism and the National Advisory Council on Drug Abuse - September 12, 2011

Agenda

About Mark Keller

About the Honoree - John C. Crabbe, Ph.D.

Mark Keller Lecture Program

Agenda

Exhibit Schedule

Research Gallery

Publications

Alcohol Alert

Alcohol Alert Archives

Alcohol Research & Health

Alcohol Research & Health Archives

Alcohol Research & Health Ordering Information

Newsletter

Pamphlets and Brochures

Professional Education Materials

Clinical Guidelines l Related Resources

CME/CE Credit for Online Training

NIAAA Clinician's Guide Online Training

Alcohol Screening and Brief Intervention for Youth: A Practitioner's Guide

Alcohol Screening and Brief Intervention for Youth: A Practitioner's Guide - Related Resources

Surveillance Reports and Epidemiologic Manuals

Resources

Database Resources and Statistical Tables

Data/Statistical Tables

Adults

Percentage of adults who reported current drinking by state and gender, BRFSS, 1984–2008.

Percentage of adults who reported current drinking by state and gender, BRFSS, 1984–2002

Percentage of adults who reported drinking and driving* by state and gender, BRFSS, 1984–2008.

Percentage of adults who reported heavy drinking by state and gender, BRFSS, 1984–2008.

Percentage of adults who reported binge drinking by state and gender, BRFSS, 1984–2003 (Continued).

Percentage of adults who reported binge drinking by state and gender, BRFSS, 1984–2008.

Alcohol Consumption

Trends in the prevalence of alcohol use among tenth graders: Monitoring the Future Study, 1991–2007.

Percent distribution of heavy drinking days (5+ drinks/day) for males 18 years of age and older according to selected characteristics: United States, NHIS, 1997–2008.

Trends in the prevalence of alcohol use among high school seniors: Monitoring the Future Study, 1975–2007.

Percent who drink beverage alcohol, by gender, 1939–2008.

Drinking status* (in percents) of men and women by selected demographics: NHIS, 1990.

Percent distribution of the drinking levels of females 18 years of age and older according to selected characteristics: United States, NHIS, 1997–2008.

Trends in the prevalence of reporting as having been drunk among eighth graders: Monitoring the Future Study, 1991–2007.

Percent distribution of heavy drinking days (5+ drinks/day) for females 18 years of age and older according to selected characteristics: United States, NHIS, 1997–2008.

Distribution of Mexican-American, Cuban-American, and Puerto Rican drinking levels by age and sex: Hispanic HANES, 1982/84. (Numbers in thousands)

Percent distribution of current drinking status, drinking levels, and heavy drinking days by sex for persons 18 years of age and older: United Status, NHIS, 1997–2008.

Percent reporting alcohol use in the past year by age group and demographic characteristics: NSDUH (NHSDA), 1994–2002[1].

Percent reporting alcohol use in lifetime by age group and demographic characteristics: NSDUH (NHSDA), 1994–2002

Trends in the prevalence of reporting as having been drunk among twelfth graders: Monitoring the Future Study, 1991–2007.

Percent distribution of usual drinking level in the past year among current drinkers combined with former drinkers and lifetime abstainers by age according to selected respondent characteristics: United States, NLAES, 1992.

Percent reporting alcohol use in the past month by age group and demographic characteristics: NSDUH (NHSDA), 1994–2002[1].

Alcohol consumption levels of persons 18 years of age and over, according to sex, United States, selected years, 1971-1988.

Alcohol consumption levels by sex, age, and education: NHIS, 1987 and 1992.

Distribution of drinking levels of white non-Hispanics and black non-Hispanics by age and sex: NHIS, 1983. (Numbers in thousands).

Percent reporting heavy alcohol use[6] in the past month by age group and demographic characteristics: NSDUH (NHSDA), 1994–2002[1].

Percent distribution of usual drinking level in the past year among current drinkers combined with former drinkers and lifetime abstainers by sex according to selected respondent characteristics: United States, NLAES, 1992.

Distribution of drinking levels of white non-Hispanics and black non-Hispanics by age and sex, NHIS, 1988 (Numbers in thousands).

Trends in the prevalence of reporting as having been drunk among tenth graders: Monitoring the Future Study, 1991–2007.

Percent distribution of days of alcohol use in past month by demographic characteristics: NSDUH (NHSDA), 1994–2002[1].

Trends in the prevalence of alcohol use among eighth graders: Monitoring the Future Study, 1991–2007.

Percent distribution of the drinking levels of males 18 years of age and older according to selected characteristics: United States, NHIS, 1997–2008.

Drinking status* (in percents) of men and women by selected demographics: NHIS, 1985.

Alcohol Dependence

Twelve-month prevalence and population estimates of DSM-IV alcohol abuse by age, sex, and race-ethnicity: United States, 2001–2002 (NESARC)*

Trends in the 12-month prevalence of DSM-IV alcohol dependence by age, sex, and race-ethnicity: United States, 1991–1992 (NLAES) and 2001–2002 (NESARC)*

Twelve-month prevalence and population estimates of DSM-IV alcohol dependence by age, sex, and race-ethnicity: United States, 2001–2002 (NESARC)*

Trends in the 12-month prevalence of DSM-IV alcohol abuse by age, sex, and race-ethnicity: United States, 1991–1992 (NLAES) and 2001–2002 (NESARC)*

Alcohol Sales

Volume beverage and ethanol consumption for States, census regions, and the United States, 1970–2007. (Volume and ethanol in 1,000 of gallons)

Per capita and per drinker ethanol consumption for selected States, 1986-99. (Based on estimates of abstention among population age 18 and older in the Behavioral Risk Factors Survey, Centers for Disease Control and Prevention)

Apparent per capita ethanol consumption for the United States, 1850–2007. (Gallons of ethanol, based on population age 15 and older prior to 1970 and on population age 14 and other thereafter).

Per capita ethanol consumption for States, census regions, and the United States, 1970–2007. (Gallons of ethanol, based on population age 14 and older)

Economic Data

Economic costs to society of alcohol abuse and alcoholism, United States, 1983

Updated cost estimates for 1992 and inflation- and population-adjusted costs of alcohol and drug abuse for 1995 [in millions of current-year dollars

Costs to society of alcohol abuse, other drug abuse, and mental illness, United States, 1980 [in millions of dollars]

Economic costs of alcohol and drug abuse in the United States, 1992 (in millions of dollars)

Estimated economic costs of alcohol abuse, 1985 and 1990

Estimated economic costs of alcohol abuse in the United States, 1992 and 1998[a]

Hospital Discharges

Number of first-listed alcohol-related diagnoses for U.S. population aged 15 years and older by sex and age: NHDS, 1979–2006.

Number of all-listed alcohol-related diagnoses for U.S. population aged 15 years and older by sex and age: NHDS, 1979–2006.

Rate of all-listed alcohol-related diagnoses for U.S. population aged 15 years and older by sex and age: NHDS, 1979–2006.

Rate of first-listed alcohol-related diagnoses for U.S. population aged 15 years and older by sex and age: NHDS, 1979–2006.

Average length of stay (in days) for first-listed alcohol-related diagnoses by sex and age: NHDS, 1979–2006.

Liver

Five-year annual moving average of age-specific death rates, and age-adjusted death rates* from liver cirrhosis with and without mention of alcohol, by Hispanic subgroup and sex, United States, 2000–2005.

Five-year annual moving average of age-specific death rates, and age-adjusted death rates* from all liver cirrhosis by Hispanic subgroup and sex, United States, 2000–2005.

Age-specific number of deaths from all cirrhosis by race, Hispanic origin, and sex, United States, 1970–2005.

Age-specific number of deaths from liver cirrhosis with and without mention of alcohol, by Hispanic subgroup and sex, United States, 2000–2005.

Age-specific number of deaths from all liver cirrhosis by Hispanic subgroup and sex, United States, 2000–2005.

Age-specific and age-adjusted death rates* for all cirrhosis by race, Hispanic origin, and sex, United States, 1970–2005.

Age-adjusted death rates* per 100,000 population of liver cirrhosis reported with and without mention of alcohol by sex, race, and Hispanic origin,** United States, 1991–2005.

Age-specific number of deaths for cirrhosis with and without mention of alcohol, United States, 1970–2005.

Age-specific and age-adjusted death rates* for cirrhosis with and without mention of alcohol, United States, 1970–2005.

Age-adjusted death rates* per 100,000 population of liver cirrhosis reported with and without mention of alcohol by race and sex, United States, 1970–2005.

Age-adjusted death rates* of liver cirrhosis by sex: death registration States, 1910–32, and United States, 1933–2005.

Mental and Physical Health

Rate per 1,000 population of selected DSM-IV psychiatric disorders, [1] by sex, according to drinking status [2] in the past year, United States, NESARC, 2001–2002.

Rate per 1,000 population of selected DSM-IV psychiatric disorders,[1] by sex, according to average drinking level [2] in the past year, among current drinkers, [3] United States, NESARC, 2001–2002.

Rate per 1,000 population of selected DSM-IV psychiatric disorders [1], by sex, according to DSM-IV alcohol use disorders in the past year, among current drinkers, [2] United States, 2001–2002.

Rate per 1,000 population of selected DSM-IV psychiatric disorders, [1] by sex, according to having exceeded daily and weekly low-risk drinking limits [2] in the past year, among current drinkers, [3] United States, 2001–2002.

Rate per 1,000 population of selected past-year health conditions, by sex, according to DSM-IV alcohol use disorders in the past year, among current drinkers, [1] United States, 2001–2002.

Rate per 1,000 population of selected past-year health conditions, by sex, according to drinking status [1] in the past year, United States, NESARC, 2001–2002.

Rate per 1,000 population of selected past-year health conditions, by sex, according to having exceeded daily and weekly low-risk drinking limits [1] in the past year, among current drinkers, [2] United States, 2001–2002.

Rate per 1,000 population of selected past-year health conditions, by sex, according to average drinking level [1] in the past year, among current drinkers, [2] United States, NESARC, 2001–2002.

Other

Rate per 100,000 population of selected past-year health conditions by sex according to usual drinking level[1] in the past year among current drinkers[2]: NLAES, United States, 1992.

Rate per 100,000 population of selected past year health conditions by sex according to drinking status[1] in the past year: NLAES, United States, 1992.

Knowledge of health risks of heavy drinking[1] and fetal alcohol syndrome (FAS), women and men ages 18 to 44 years, 1985 and 1990.

Number of deaths and age-adjusted death rates[1] per 100,000 population for categories of alcohol-related (A-R) mortality, United States and States, 1979-96.

Traffic Crashes

Decedent's role in alcohol-related traffic crash fatalities, United States, 1982–2004.

Alcohol-related traffic fatalities according to age groups, United States, 1982–2004.

Drivers involved in fatal traffic crashes and given BAC tests, according to State and injury severity, United States, 1982–2004.

Percentage* distributions of BACs** among alcohol–involved drivers, according to sex and age, United States, 1982–2004.

Years of potential life lost (YPLL) from total and alcohol-related traffic crashes according to sex, United States, 1982–2004.

Total and alcohol-related traffic fatality rates per 100 million VMT,* 100,000 population, 100,000 registered vehicles, and 100,000 licensed drivers, United States, 1982–2004.

Traffic crashes, traffic crash fatalities, and alcohol-related traffic crash fatalities, United States, 1982–2004.

Alcohol involvement (AI)* among young drivers under age 21 and drivers ages 21 and older in fatal traffic crashes, United States, 1982–2004.

Driver's alcohol involvement* in fatal traffic crashes, according to sex and age, United States, 1998 and 2004.

Youth

YRBS: Prevalence of binge drinking in the past 30 days, by grade and sex, United States, 1991–2007

NSDUH: Mean frequency of drinking in the past 30 days, by age, sex, and race/Hispanic origin, among current drinkers ages 12–20, United States, 1991–2007.

Percentage of students at alternative high schools who rode with a driver who had been drinking alcohol, who drove after drinking alcohol, who drank alcohol in the past 30 days, who drank alcohol before age 13, . . .

NSDUH: Average total number of drinks in the past 30 days, by age, sex, and race/Hispanic origin, among current drinkers ages 12–20, United States, 1991–2007.

Percentage of students who had 5 or more drinks of alcohol in a row on 1 or more of the past 30 days, by geographic area according to sex: YRBS, 1991–2005, biennially.

NSDUH: Prevalence of driving a vehicle while under the influence of alcohol in the past 12 months, by age, sex, and race/Hispanic origin, among 12–20 year olds, United States, 1995–2007.

YRBS: Prevalence of drinking in the past 30 days, by grade and sex, United States, 1991–2007.

NSDUH: Prevalence of binge drinking in the past 30 days, by age, sex, and race/Hispanic origin, among 12–20 year olds, United States, 1991–2007.

NSDUH: Mean quantity of drinking on drinking days in the past 30 days, by age, sex, and race/Hispanic origin, among current drinkers ages 12–20, United States, 1991–2007.

Percentage of students who at least had one drink of alcohol on 1 or more of the past 30 days, by geographic area according to sex: YRBS, 1991–2005, biennially.

Percentage of college students who rode with a driver who had been drinking alcohol, who drove after drinking alcohol, who drank alcohol in the past 30 days, who drank alcohol 1 or more times on 20 or more of the past 30 days, . . .

NSDUH: Mean age at first use of alcohol, by age, sex, and race/Hispanic origin, among ever drinkers ages 12–20, United States, 1991–2007.

Percentage of students who during the past 30 days drove a vehicle 1 or more times when they had been drinking alcohol, by geographic area according to sex: YRBS, 1991–2005, biennially.

NSDUH: Prevalence of drinking in the past 30 days, by age, sex, and race/Hispanic origin, among 12–20 year olds, United States, 1991–2007.

Percentage of students who had their first drink of alcohol other than a few sips before age 13, by geographic area according to sex: YRBS, 1990, 1991–2005, biennially.

Percentage of students who during the past 30 days rode 1 or more times in a vehicle driven by someone who had been drinking alcohol, by geographic area according to sex: YRBS, 1991–2005, biennially.

Expert Panel for the Alcohol Policy Information System (APIS)

COMBINE Data Set

Graphics Gallery

Cardiovascular System

Myosin and actin protein molecules contained in muscles

A heart in dilated cardiomyopathy

Diagram of the heart

Diagram of the cardiovascular system

The heart's electrical system

Intracellular Binding Sides

Digestive Tract

Anatomy of the upper aero-digestive tract

Endocrine/Reproductive System

Schematic representation of the HPA, HPG, and HPT axes

Location of the components of the hypothalamic-pituitary-adrenal (HPA) axis

Alcohol blocks the ability of IGF-1 to induce the release of LH in prepubertal female rats

Schematic representation of the possible influence of b-endorphin (b-EP) on dopamine release in the nucleus accumbens (NAc)

Lengthwise view of the rat brain

Proposed action of IGF-1 in females as puberty approaches

Epidemiology

Trends in percent distribution of principal (first–listed) diagnoses among discharges with principal (first–listed) mention of an alcohol–related diagnosis, 1979–2006

Age-specific death rates of liver cirrhosis, United States, 1970-2005

Age-adjusted death rates of liver cirrhosis by sex and race, United States, 1970-2005

Percent distribution of principal (first–listed) diagnoses among discharges with any (all–listed) mention of an alcohol–related diagnosis, 2006

Total per capita consumption in gallons of ethanol by State, United States, 2006

Prevalence of underage binge drinking, by sex, 1991–2007

Total per capita ethanol consumption, United States, 1935–2006

Percent change in per capita ethanol consumption, United States, 1977–2006

Age-adjusted death rates of liver cirrhosis by sex (death registration States, 1910-1932, and United States, 1933-2005)

Prevalence of driving a vehicle while under the influence of alcohol in the past 12 months among 12–20 year olds, by sex and race/Hispanic origin, National Survey on Drug Use and Health, 1995–2007

Median age at first use of alcohol among 12–20 year olds, by sex and race/Hispanic origin, National Survey on Drug Use and Health, 1991-2007

Average total number of drinks in the past 30 days among 12–20 year olds, by sex and race/Hispanic origin, National Survey on Drug Use and Health, 1991–2007

Average annual deaths per 100,000 population from causes with explicit mention of alcohol by county, United States, 1986-90

Percentage of alcohol involvement among young drivers ages 16 to 20 and drivers 21 and older in fatal traffic crashes, United States, 1982–2004

Per capita ethanol consumption by beverage type, United States, 1977–2006

Decedent’s role in nonalcohol–related traffic crash fatalities, United States, 2004

Total and alcohol–related traffic fatality rates per 100 million vehicle miles traveled (VMT), United States, 1977–2004

Decedent’s role in alcohol–related traffic crash fatalities, United States, 2004

Prevalence of underage drinking in the past 30 days, by sex, 1991–2007

Percentage of alcohol involvement among drivers in fatal traffic crashes, according to age, United States, 1998 and 2004

Trends in percent of discharges with principal (first–listed) or any (all–listed) mention of an alcohol–related diagnosis among all discharges, 1979–2006

Prevalence of drinking in the past 30 days among 12–20 year olds, by sex and race/Hispanic origin, National Survey on Drug Use and Health, 1991–2007

Percent distribution of principal (first–listed) diagnoses among discharges with principal (first–listed) mention of an alcohol–related diagnosis, 2006

Fetal Alcohol Syndrome

Embryonic development of the nervous system

Craniofacial features associated with fetal alcohol syndrome

Areas of the brain that can be damaged in utero by maternal alcohol consumption

Reported incidence rate of fetal alcohol syndrome, by year of birth, from the Birth Defects Monitoring Program of the Centers for Disease Control and Prevention, 1979-1992.

Genetics

The hormone cortisol was measured in both family history-positive (FHP)and family history-negative (FHN) subjects before consuming alcohol

The conversion of genetic information into protein without and with antisense RNA treatment

Outline of the subtractive RNA hybridization process

Influences on offspring phenotype in an intact nuclear family compared to influences on offspring phenotype in an adoptive family

Regulation of gene expression through promoters and transcription factors

Strategy for generating conventional knockout mice

Immune System

Outcome of two types of treatment for pneumonia in alcohol-treated animals

Three stages of carcinogenesis

Liver

Varices—A complication of alcoholic liver disease

Model showing the link between endotoxin release and liver injury

Structure of the liver's lobules

Changes in Flux Control CoEfficients in Glycolysis

Harmful Byproducts Resulting from Alcohol Metabolism

Alcoholic Liver Disease

Ketone Bodies and Insulin Increase the Efficiency of Mitochondria Energy Production

Effect of Insulin and Ketone Bodies on the Glycolytic Intermediate in the Heart

Structural changes of cells undergoing necrosis or apoptosis

Ketone Bodies on TCA Cycle Intermediates

Cells of the hepatic sinusoid

Pericentral fibrosis in alcoholic liver disease

Progression of liver injury in alcoholic fibrosis

Metabolism

Generation of reactive oxygen by cytochrome P450 2E1 (CYP2E1)

Metabolism of ethane to produce alcohol and water

Oxidative pathways of alcohol metabolism

The Figure depicts an overall hypothesis for the pathogenesis of alcoholic pancreatitis

Relative sizes and positions of the seven human alcohol dehydrogenase (ADH) genes on the long arm of chromosome 4 (i.e., chromosome 4q)

Voluntary ethanol consumption according to Aldh2 alleles in UChB and UChA Wistar-derived rats

The variability of cytochrome P450 2E1 (CYP2E1) from 18 human liver samples

Gene structure and gene expression in higher organisms

Pathways of ethanol metabolism and their role in carcinogenesis

Schematic representation of three alternative models that account for the role of acetaldehyde in ethanol’s (ETOH’s) effects

Schematic representation of the metabolism of ethanol (ETOH) and the effects of aldehyde dehydrogenase (ALDH) inhibitors and catalase modulators

Illustrated are the pancreas, gallbladder, and duodenum

Neuroscience

Schematic representation of the gamma-aminobutyric acid (GABAA) receptor

How the neurotransmitter GABA affects nerve signal transmission in the absence of alcohol (normal state)

Effects of selective attention on exogenous ERPs elicited by stimuli in three sensory modalities differ in terms of morphology and scalp topography

Pictorial representation of the Himmelsbach hypothesis as it applies to alcohol use

Regions of the brain involved in the processes of reward and reinforcement

Performance examples of a control subject and an alcoholic patient on the go/no-go task

Schematic drawing of a ligand-gated ion channel (left) showing the confluence of individual subunit proteins that define a pore where the ions flow across the cell membrane

PET and MRI images of a male alcoholic

How the neurotransmitter GABA affects nerve signal transmission after chronic alcohol exposure and during withdrawal

Adolescent Brains Show Reduced Reward Anticipation

Topography of ERP response to tactile stimulus at approximately 50 ms after stimulus presentation

How the neurotransmitter glutamate affects nerve signal transmission in the absence of alcohol (normal state)

Electroencephalographic (i.e., brain wave) tracings of the waveform P300

Major Components of a Typical Neuron

How the neurotransmitter glutamate affects nerve signal transmission in the presence of alcohol

Schematic of a lengthwise cross-section through the human brain

Animal behavioral paradigms used to explore the positive and negative reinforcing actions of alcohol and other drugs

Comparison of two female subjects who had volumetric MRIs created in a GE 1.5 Tesla MRI machine

Parts of the brain involved in alcohol/nocotine dependence and psychiatric disorders

Areas of the brain vulnerable to damage by alcohol

Alcoholic male subject's PET image is pseudocolored to show areas of increased and decreased metabolic

The NMDA receptor complex

Schematic representation of some of the major neurochemical systems affected by alcohol

Regions in the brain affected by alcohol

Schematic drawing of the γ-aminobutyric acid receptor (GABAA) ligandgated ion channel complex. The receptor molecule is formed by the confluence of five subunit proteins

Brain activity during alcohol intoxication

Schematic drawing of a neuron showing dendrites, where neurons receive chemical input from other neurons; soma (cell body); and axon terminal, where neurons communicate information to other cells

Nerve signal transmission in the nervous system

Neurotransmitters with discrete localization within the brain

Cells from patient with hepatic encephalopathy

Echo planar magnetic resonance images (fMRI)

Alcohol interacts with cell membranes

Schematic representation of the two most common subtypes of nAChRs

Schematic drawing of a synapse between two neurons

Interactive effects of alcohol and nicotine on dopamine release in the rat brain

Alcohol’s effects on endogenous opioids in the brain

How the neurotransmitter GABA affects nerve signal transmission in the presence of alcohol

Images comparing a healthy control man with an alcoholic man

How the neurotransmitter glutamate affects nerve signal transmission after chronic alcohol exposure and during withdrawal

Pharmacology

Opiate receptor activation of a nerve and blockage of the signal by naltrexone

Treatment & Prevention

The number and ownership of alcoholism treatment units in 1982 and 1990

An ecological model of drinking behavior

Age-adjusted death rates1 from liver cirrhosis by sex (death registration States, 1910–32, and United States, 1933–2005)

Apparent per capita ethanol consumption, United States, 1977–2006.

Trends in percent of discharges with principal (first-listed) or any (all-listed) mention of an alcohol-related diagnosis among all discharges, 1979–2006.

Percentage of alcohol involvement among drivers in fatal traffic crashes, according to age, United States, 1998 and 2004

Trends in percent distribution of principal (first-listed) diagnoses among discharges with principal (first-listed) mention of an alcohol-related diagnosis, 1979–2006.

Decedent's role in alcohol-related traffic fatalities, United States, 2004

Age–adjusted death rates from all liver cirrhosis by race, and sex, United States, 1970–2005.

Age-specific death rates of liver cirrhosis, United States, 1970–2005.

Decedent's role in nonalcohol-related traffic fatalities, United States, 2004.

Percent distribution of principal (first-listed) diagnoses among discharges with principal (first-listed) mention of an alcohol-related diagnosis, 2006

Total per capita alcohol consumption in gallons of ethanol by State, United States, 2006

Total and alcohol-related traffic fatality rates per 100 million vehicle miles traveled (VMT), United States, 1982–2004

Total per capita ethanol consumption, United States, 1935–2006

Percent change in per capita alcohol consumption, United States, 1977–2006.

Percent distribution of principal (first-listed) diagnoses among discharges with any (all-listed) mention of an alcohol-related diagnosis, 2006

Percentage of alcohol involvement among young drivers under age 21 and drivers ages 21 and older in fatal traffic crashes, United States, 1982–2004

Related Websites

Treatment Referral Information

Research Guidelines and Resources

National Advisory Council on Alcohol Abuse and Alcoholism - Recommended Council Guidelines on Ethyl Alcohol Administration in Human Experimentation - Revised May 2005

Task Force on Recommended Alcohol Questions - National Council on Alcohol Abuse and Alcoholism Recommended Sets of Alcohol Consumption Questions - October 15-16, 2003

Research Information

Extramural Research Sponsored by NIAAA

Contracts

Research and Development (R&D) Contracts

NIAAA Advisory Council Subcommittee Review of Extramural Portfolio

Advisory Council Subcommittee Review of Extramural Research Portfolio for Epidemiology, May 5-6, 1999, Washington, DC

Advisory Council Subcommittee Review of Extramural Research Portfolio for Treatment, November 8-9, 1999, Bethesda, MD

Advisory Council Subcommittee Review of Extramural Research Portfolio for Neuroscience and Behavior, May 11-13, 1998, Washington, DC

Advisory Council Subcommittee Review of Extramural Research Portfolio for Fetal Alcohol Syndrome (FAS) - May 12-13, 1997, Bethesda, MD

Advisory Council Subcommittee Review of Extramural Research Portfolio for Genetics - November 3-4, 1997, Rockville, MD

Extramural Science Advisory Subcommittee on FAS - Recommendations on Areas of Additional FAS Research

Division of Epidemiology and Prevention Research Strategic Planning Document

Advisory Council Subcommittee Review of Extramural Research Portfolio for Biomedical Research - May 2-3, 2000, Bethesda, MD

Advisory Council Subcommittee Review of Extramural Research Portfolio for Prevention, October 21-22, 1998, Washington, DC

NIAAA Research Areas

Alcohol: A Priority for HIV/AIDS Research

Alcohol and AIDS: A Guide to Research Issues and Opportunities

Alcohol and AIDS Research Program Coordinator

NIAAA Resources for Applicants & Grantees

Certificates of Confidentiality Kiosk

NIAAA Guidelines for Data and Safety Monitoring Plans

Secondary Analysis of Existing Alcohol Epidemiology Data (R03 and R21)

Structural Interventions, Alcohol Use, and Risk of HIV/AIDS (R03 and R21)

MERIT Award (R37) Procedural Guidelines--NIAAA

Mechanisms of Alcohol-Induced Tissue Injury (R21)

Mechanisms of Alcoholic Pancreatitis (21)

Terrorism and Bioterrorism Related Research Opportunities

Mechanisms of Alcoholic and Nonalcoholic Fatty Liver (Steatosis) (R21)

Certificates of Confidentiality (NIAAA-Specific): Protecting the Identity of Research Subjects

Applications Requesting $500,000 or more in Direct Costs

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NIAAA-Funded Collaborative Research Programs

Gene Array Technology Center (GATC) for Alcohol Research

Center for Inherited Disease Research

Human "Brain Bank" Tissue for Alcohol Research

Distribution Agreement

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Requests for Applications

Further Information in Response to Inquiries on the Education Component Within the Comprehensive Center Applications (P60)

Supplemental Instructions for Preparing an Alcohol Research Center Grant Application (Revised March 2011)

Research Programs for Small Businesses

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Clinical Trial Regulations, Policies and Guidance

Pharmaceutical Companies

Post-Doctorate Postion in France: The endocannabinoid system in inflammatory liver diseases

Post-Doctorate Position in France: Coupling and uncoupling of monoaminergic systems and drugs of abuse

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Supplemental Information-NIAAA Institutional National Research Service Awards (T32)

Selected Health Disparity Grants/Programs

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Supplemental Instructions for Preparing a Program Project Application (P01)

Post Doctoral Position in France: Role of the integrated stress response in alcoholic liver disease

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About COMBINE

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Clinical Trials

Post-Doctorate Position in France: Long term evolution of alcohol drinking and tobacco smoking habits - Effects on health risks

Post-Doctoral Position in France: Neuropsychology and brain imaging in adolescents at risk for addiction

Medications Development Program Overview

Post-Doctoral Positions in France

NIAAA Institutional Research Training Programs

Further Information in Response to Inquiries on the Education Component within the Comprehensive Center Applications (P60)

NIAAA-Funded Alcohol Research Centers

NIAAA FY 2010 Financial Management Plan

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NIAAA FY 2011 Financial Management Plan

NIAAA FY 2012 Financial Management Plan

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NIAAA Research Supplements to Promote Diversity in Health-Related Research (PA-12-149)

Intramural Research Conducted at NIAAA

About DICBR

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Laboratory for Integrative Neuroscience (LIN)

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Useful Links for the Section on Neuronal Structure

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MRIs Show Adolesent-Adult Differences in Reward Anticipation

Changes of Flux Control CoEfficients in Glycolysis

The Ketone Bodies on TCA Cycle Intermediates

Performance examples of a control subject and an alcoholic patient on the go/no-go task

Role of NFkB and p44/42 pathways in lipopolysaccharide-induced increase of anandamide synthesis in RAW264.7 macrophages

Bimodal action of ethanol on HUVEC. AT, adenosine transporter; A1 R, adenosine A1 receptor.

Alcoholic male subject's PET image is pseudocolored to show areas of increased and decreased metabolic activity

Cirrhotic macrophages elicit CB1-mediated hypotension

Effects of selective attention on exogenous ERPs elicited by stimuli in three sensory modalities differ in terms of morphology and scalp topography

Topography of ERP response to tactile stimulus at approximately 50 ms after stimulus presentation

Echo planar magnetic resonance images (fMRI)

Ketone Bodies and Insulin Increase the Efficiency of Mitochondria Energy Production

Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis

The Effect of Insulin and Ketone Bodies on the Glycolytic Intermediate in the Heart

Comparison of two female subjects who had volumetric MRIs created in a GE 1.5 Tesla MRI machine

CB1 antagonist reverses hypotension in cirrhotic rats

Detection of a functional stop codon that can cause severe impulsivity.

Functional NPY diplotypes predict fMRI responses to an emotional probe

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