Laboratory of Molecular and Cellular Neurobiology

Li Zhang

Education

Doctor of Medicine, 1984
Beijing Medical University
Beijing, P.R. China

Research Interests

Molecular Neurobiology and Pharmacology

Selected Publications

Kim YS, Zhang H, Kim HY. Profiling neurosteroids in cerebrospinal fluids and plasma by gas chromatography/electron capture negative chemical ionization mass spectrometry . Analytical Biochem 2000;277:187-195.   pdf

Li B, Zhang H, Akbar M, Kim HY. Negative regulation of cytosolic phospholipase A(2) by melatonin in the rat pineal gland . Biochem J 2000;351:709-716.   pdf

Okada M, Zhang L, Russell JT, Holtzclaw L, Ozaki N, Weight FF, Linnoila M, Goldman D: Reduction of human 5HT2C receptor function by an abundant naturally occurring amino acid substitution Cys23Ser. Submitted

Yu Y, Zhang L, Yin X, Sun H, Uhl GR,Wang JB: m opioid receptor phosphorylation , desensitization, and ligand efficacy. J Biol Chem 1997;272:28869-28874.

Zhang L, Peoples RW, Oz M, Weight FF, Brauneis U: Potentiation of NMDA receptor-mediated responses by dynorphin at low extracellular glycine concentrations. J Neurophysiol 1997;78:582-590. 

Zhang L, Oz M, Stewart RR, Peoples RW, Weight FF: Volatile general anasthetic actions on recombinant nACha7, 5-HT₃ and chimeric nACha7-5-HT₃ receptors expressed in Xenopus oocytes. Br J Pharmacol 1997;120:353-355.

Yu D, Zhang L, Eilsele J-L, Bertrand D, Changeux J-P, Weight FF: Ethanol inhibition of nicotinic acetylcholine type a7 receptors involves the amino-terminal domain of the receptor. Mol Pharmacol 1996;50:1010-1016.

Brauneis U, Oz M, Peoples RW, Weight FF, Zhang L: Differential sensitivity of recombinant NMDA receptor subunits to inhibition by dynorphin. J Pharmacol Exp Ther 1996;279:1063-1068.

Zhang L, Yu Y, Mackin S, Weight FF, Uhl GR, Wang JB: Differential m opiate receptor phosphorylation and desensitization induced by agonists and phorbol esters. J Biol Chem 1996;271:11449-11454.   pdf

Wang JB, Zhang L, Oz M, Pei G, Uhl GR: Mu-receptor phosphorylation: Biomedical and functional studies. Analgesia 1995;1:846-849.

Fan P, Oz M, Zhang L, Weight FF: Effect of Cocaine on 5-HT₃ receptor-mediated ion current in Xenopus oocytes. Brain Res 1995;673:181-184.

Lappalainen J, Zhang, L, Dean M, Oz M, Ozaki N, Yu D-H, Virkkunen M, Weight FF, Linnoila M, Goldman D: Identification, expression and pharmacology of a cys23-ser23 substitution in the human 5-HT2c receptor gene. Genomics 1995;27:274-279.

Zhang L, Oz M,Weight FF: Potentiation of 5-HT₃ receptor-mediated responses by protein kinase C activation. Neuroreport 1995;6:1464-1468.

Mailing Address   

Laboratory of Molecular and Cellular Neurobiology
NIH NIAAA DICBR
Park Bldg., Rm 150
12420 Parklawn Dr., MSC 8115
Bethesda, Maryland 20892-8115

E-Mail: lzhang@.niaaa.nih.gov