Actions of the brain’s γ-aminobutyric acid (GABA) system. In the presence of ethanol, GABA activity is enhanced, resulting in greater Cl- influx into the postsynaptic neuron and, consequently, greater inhibition of the neuron.

SOURCE: Clapp, P.; Bhave, S.V.; and Hoffman, P.L. How adaptation of the brain to alcohol leads to dependence: A pharmacological perspective. Alcohol Research & Health 31(4):310–339, 2008.

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Updated: October 2009