Actions of the brain’s γ-aminobutyric acid (GABA) system. GABA acts in part through GABAA receptors, which serve as ion channels for chloride ions (Cl-). Greater influx of Cl- into the neuron makes it more difficult for the cell to generate a new nerve impulse.
SOURCE: Clapp, P.; Bhave, S.V.; and Hoffman, P.L. How adaptation of the brain to alcohol leads to dependence: A pharmacological perspective. Alcohol Research & Health 31(4):310–339, 2008.
Download this file as a PDF
Updated: October 2009