Lucas Glover

Lucas Glover, PhD, Post-doctoral fellow
Lucas.Glover@nih.gov
Current projects: Neural circuits of stress and emotion

Dr. Glover joined the Laboratory of Behavioral and Genomic Neuroscience at the beginning of 2016. He is investigating brain-wide neural networks involved in representing ambiguous or reliable predictors of threat and how uncertainty generated in the animal promotes maladaptive behaviors, such as generalized anxiety-like behavior. He is currently using behavioral, immunohistochemical, and circuit-specific manipulations to probe these neural ensembles. This work is particularly important for understanding 1) how unreliable threat-related cues can induce generalized anxiety-like behaviors and 2) the specific circuits that mediate these behaviors.

Another ongoing project within the lab includes a ‘risky’ decision-making paradigm involving ambiguous threat and specific neurotransmitter interactions within brain. Along with Abby Postle, we are using behavioral, pharmacological, immunohistochemical, in situ hybridization, and cell type-specific circuit manipulations that contribute to ‘risky’ decision-making. This work is particularly important for understanding 1) how risk of threat and specific receptors influence decisions and 2) the circuits that mediate risky decisions and how these decisions may relate to addiction.

Dr. Glover graduated from Allegheny College with a BS in Neuroscience and Psychology. He then continued onto a collaborative doctoral training program between the National Institutes of Mental Health and the University of Oxford with Dr. Heather Cameron (NIH) and Prof. David Bannerman (Oxford). There he began investigating how the hippocampus and adult-born neurons mediate behaviors toward ambiguous cues of threat or reward and protect against stress-related disorders.

 


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