The National Institutes of Health (NIH) has issued the folllowing notice: "Request for Information (RFI): National Longitudinal Study of Neurodevelopmental Consequences of Substance Use."
Notice Number: NOT-DA-14-014

Key Dates

  • Release Date: July 2, 2014
  • Response Date: August 31, 2014

From the Notice: The NIH is exploring optimal ways to configure a large longitudinal cohort study to prospectively examine the effects of substance use on the human brain during early adolescence into young adulthood.

Input for this project from the extramural community was initially provided in an open on-site workshop at the NIH held on May 27-28, 2014. A full summary of recommendations and commentary from this workshop is available at

The attendees expressed that the most useful study would address all of the following research questions:

  • What is the impact of diverse patterns of substance use on the structure and function of the developing brain, as revealed by brain imaging?
  • What are the consequences of substance use on physical health, psychosocial development, information processing, learning, memory, academic achievement, motivation, emotional regulation, and other behaviors?
  • How does substance use affect the expression of psychopathology, including substance use disorders, and how does the emergence of psychopathology influence substance use.
  • What factors (prenatal exposure, genetic, epigenetic, neurobiological, psychosocial, family history) influence substance use and its consequences during development?
  • In what way does use of each substance contribute to the use of other substances (gateway interactions)?

This RFI solicits further guidance and input to this project from the extramural research community and other public stakeholders.

To learn how to submit a response and for more details, please visit