Clinical NeuroImaging Research Core
What we do
The Clinical NeuroImaging Research Core (CNIRC) serves two functions: Conducting independent addiction neuroimaging studies and providing imaging expertise, through imaging collaborations and support to clinical investigators.
Research interests include:
- Identify and investigate the neural substrates and neurocircuitries associated with stages of alcohol use and misuse.
- Examine the dynamic relationship between brain structure and function and alcohol use disorders.
- Utilize imaging phenotypes to establish efficacy of experimental treatments and therapies.
- Utilize imaging biomarkers to predict treatment outcome and relapse.
Clinical collaborations and support include:
- Enhance imaging capabilities
- Prototype paradigms and methodologies
- Assist PI’s in protocol development with imaging components, including, for example advice on practicality, power analysis, etc.
- Conduct imaging components of the studies including:
- Implement imaging paradigms
- Supervise/conduct scanning sessions
- Perform image processing
- Perform imaging analyses
- Present imaging results
- Develop and provide imaging informatics
- Standardize and track imaging data
- Provide imaging study database
- Provide recommendations to the OSD and OCD in prioritization and advance planning of the studies involving neuroimaging.
- Provide Intramural and NIH Clinical Elective Program trainings in imaging
Reza Momenan, PhD, Director
Phone: 301.451-6972
Email: reza.momenan@mail.nih.gov
Dr. Momenan has been involved in neuroimaging research studies of alcohol use disorder for more than 25 years. He has been providing expertise and support to NIAAA Intramural program on a wide spectrum of experimental design and imaging studies. His main focus of research has been design and developing experiments utilizing various MR modalities for study of motivation, impulsivity, and emotions as related to addiction. His current focus is in utilization of neuroimaging phenotypes to investigate gender differences and sub-types of alcohol use disorders. Dr. Momenan is also interested in the use of other human brain mapping approaches as well as innovative techniques such as those of real-time fMRI, machine learning algorithms to predict alcohol use disorders, treatment efficacy, and relapse.
Current Staff
Dan Rio, PhD
Physicist/Mathematician
Phone: 301.402.2994
Email: dan.rio@mail.nih.gov
Dr. Rio is a physicist/mathematician who setup the original clinical imaging facilities in NIAAA. His current interest is developing new models for analysis of functional MRI in addition to providing support in the areas of computational mathematics, mathematical modeling, image processing and experimental design.
Mike Kerich
Computer Program Specialist
Phone: 301.496.6540
Email: mike.kerich@mail.nih.gov
Michael Kerich joined NIAAA in 1986 as a Computer Specialist/Scientist after received his BS in Chemistry/Minor in Biochemistry with honors in 1982 and his BS in Computer Science in 1986. He has been involved in the collection and processing of structural and functional images for the NIAAA. He also helps retrieve and integrate psychological, genetic, and demographic data with the imaging data for analysis. He maintains the linux systems used for analysis and backups all the imaging data for the CNIRC. He also provides limited desktop support for users in the Core. He also helps develop electronic data entry forms and kiosks using Filemaker for the lab.
Samantha Fede, PhD
Postdoctoral Fellow
Phone:
Email: samantha.fede@nih.gov
Samantha Fede joined NIAAA in 2017. She received her PhD from the University of New Mexico in 2017 where her dissertation work focused on neural dynamics associated with moral cognition, particularly how substance use and psychopathy moderate those dynamics in forensic samples. Her previous research included work on using neural signal to predict treatment outcomes, and the neural correlates of delay discounting. Dr. Fede is interested in identifying novel translational applications of neuroimaging that can be used in populations with addiction to individualize treatment and intervention.
Thushini Manuweera, PhD
Postdoctoral Visiting Fellow
Phone:(301) 496-1103
Email: thushini.manuweera@nih.gov
Thushini Manuweera joined the Clinical Neuroimaging Research Core in July of 2018. She received her PhD in biomedical sciences from Rutgers, School of Graduate Studies. Dr. Manuweera’s dissertation research focused on investigating the brain network recruited when performing a visually demanding motor task with mirrored visual feedback (MVF) in healthy individuals. In addition, her research focused on understanding both functional and structural features of this MVF network associated with differences in lesion location in individuals with stroke. Dr. Manuweera is interested in investigating how neural networks relate to genetic traits and physiological impairments in alcoholics.
Sarah Dean, BS, Postbac IRTA
Phone: (301) 496-7513
Email: sarah.dean@nih.gov
Sarah Dean joined the Clinical NeuroImaging Research Core in June 2017 after completing her Bachelor of Science in Psychology at the University of Maryland. Her undergraduate research focused on exploring the hippocampal memory network in young children through neuroimaging. She now explores differences in brain structures and activity in people with and without alcohol dependence. Her other duties include recruiting, screening patients, and running neuroimaging analysis.
Emma Pearson, BS, Postbac IRTA
Phone: (301) 402-5630
Email: emma.pearson@nih.gov
Emma Pearson joined the Clinical NeuroImaging Research Core in June 2018 after completing her studies in Psychology and Sociology at the University of Michigan. Her undergraduate research focused on the development of children at risk for antisocial behaviors and psychopathy using functional MRI and gene-environment interactions. Following the completion of her fellowship at NIH, she plans to pursue a doctorate in Clinical Psychology.
Savita Madan, BS, Postbac IRTA
Phone: (301) 827-0321
Email: savita.madan@nih.gov
Savita Madan became a part of the Clinical NeuroImaging Research Core in June of 2018, after completing her Bachelor of Science in Psychology at the University of North Carolina at Chapel Hill. Her undergraduate research utilized clinical and neuroimaging approaches in a longitudinal study on a treatment-seeking, polysubstance-using population with substance use disorders. She now contributes to research that aims to better understand neurological differences in populations with and without alcohol use disorders. Savita plans to use her interest in neuroscience, interdisciplinary background in health and human behavior, and research experience to pursue a PhD in neuropsychology.
Clinical Protocols
14-AA-0094 Neural Substrate of Approach Avoidance in Alcoholism
14-AA-0066 Behavioral and Functional MRI Task Development, Implementation, and Testing
14-AA-0080 Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
15-AA-0203 Cross-Sectional and Longitudinal Study of Structural Imaging
18-AA-0098 Investigating a Response Modulation Hypothesis of Socioemotional Processing associated with Alcohol Use Disorder
View more NIAAA Clinical Protocols & link to all NIH Clinical Protocols
Selected Publications
ORIGINAL PUBLICATIONS
Erica Grodin, Lauren Sussman, Kelsey Sundby, Grace Brennan, Nancy Diazgranados, Markus Heilig, Reza Momenan, Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Link
Carlos R. Cortes, Erica N. Grodin, Claire L. Mann, Karan Mathur, Michael Kerich, Xi Zhu, Melanie Schwandt, Nancy Diazgranados, David T. George, Reza Momenan, Markus Heilig (2018), Insula Sensitivity to Unfairness in Alcohol Use Disorder, Alcohol and Alcoholism, doi: 10.1093/alcalc/agx115. PubMed
Erica N. Grodin, Carlos R. Cortes, Primvera Spagnolo, Reza Momenan (2017), Structural Deficits in Salience Network Regions Are Associated with Increased Impulsivity and Compulsivity in Alcohol Dependence, Drug and Alcohol Dependence, 2017 Oct 1;179:100-108. PubMed
Xi Zhu, Xiaofei Du, Mike Kerich, Falk W. Lohoff, Reza Momenan (2018), Random Forest Based Classification of Alcohol Dependence Patients and Healthy Controls Using Resting State MRI, Neuroscience Letters, 676 (2018) 27-33. PubMed
Vladimir V. Senatorov, Claire L. Mann, Melanie L. Schwandt, Markus Heilig, Daniel W. Hommer, Reza Momenan, Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons, Brain, 2015 Jan;138(Pt 1):69-79. PubMed
Durkee C, Sarlls J, Hommer D, Momenan R, White matter microstructure alterations: a study of alcoholics with and without post-traumatic stress disorder, PLoS One (2013) Volume 8, Issue 11, e80952, 1-10. PubMed
Leah M. Mayo, Diana Fraser, Emma Childs, Reza Momenan, Daniel Hommer, Harriet de Wit, Markus Heilig, Conditioned preference to a methamphetamine-associated contextual cue in humans, Journal of Neuropsychopharmocology (2013) 38, 921–29. PubMed
Grodin E., Lin H., Hommer, D.W., Durkee, C.A., Momenan R., Deficits in cortical, diencephalic and midbrain gray matter in alcoholism measured by VBM: Effects of co-morbid substance abuse, NeuroImage: Clinical (2013) 2: 469-76. PubMed
Momenan, R., Steckler L.E., Saad Z., van Rafelghem S., Kerich, M., and Hommer, D.W., Effects of alcohol dependence on cortical thickness (2012), Psychaiatry Research: Neuroimaging, Volume 204, Issues 2–3, 30 November (2012), Pages 101–111. PubMed
Bjork JM, Chen G, Smith AR, Hommer DW: Incentive-elicited mesolimbic activation in adolescents with externalizing disorders. Journal of Child Psychology & Psychiatry. 2010 Jul 11;51(7):827-37. PubMed
Gilman JM, Davis MB, Hommer DW: Greater activation in left hemisphere language–related regions during simple judgment tasks among substance-dependent patients in treatment for alcoholism. Alcoholism: Clinical and Experimental Research. 2010 Feb;34(2):331–41. PubMed
Bjork JM, Momenan R, and Hommer DW: Delay discounting correlates with proportional lateral frontal cortex volumes. Biological Psychiatry. 2009 Apr 15;65(8):710-3. PubMed
Bjork JM, Smith AR, Hommer DW: Striatal sensitivity to reward deliveries and omissions in substance dependent patients, NeuroImage. 2008 Oct 1;42(4):1609-21. PubMed
Gilman JM, Hommer DW. Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients. Addiction Biology. 2008 Sep;13(3-4):423-34. PubMed
Bjork JM, Knutson B, Hommer DW: Incentive-elicited striatal activation in adolescent children of alcoholics. Addiction. 2008 Aug;103(8):1308-19. PubMed
Bjork JM, Momenan R, Smith A, Hommer DW. Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients. Alcohol and Drug Dependence. 2008 May 1;95(1-2):115-28. PubMed
Gilman JM, Ramchandani VA , Davis MB , Bjork JM, Hommer DW. Why we like to drink: An fMRI Study of the Rewarding and Anxiolytic Effects of Alcohol. Journal of Neuroscience. 2008 Apr 30;28(18):4583-91. PubMed
George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt J, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M. Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science. 2008 Mar 14;319(5869):1536-9. PubMed
Gilman JM, Bjork JM, Hommer DW. Parental alcohol use and brain volumes in early- and late-onset alcoholics. Biological Psychiatry. 2007 Sep 15;62(6):607-15. PubMed
Salloum JB, Ramchandani VA, Bodurka J, Rawlings R, Momenan R, George D, Hommer DW. Blunted rostral anterior cingulate response during a simplified decoding task of negative facial expressions in alcoholic patients. Alcoholism: Clinical and Experimental Research. 2007 Sep;31(9):1490-504. PubMed
Schottenbauer MA, Hommer D, Weingartner H. Memory deficits among alcoholics: Performance on a selective reminding task. Aging, Neuropsychology, and Cognition. 2007 Sep;14(5):505-516. PubMed
Bjork JM, Smith A, Danube C, Hommer DW. Developmental differences in posterior mesofrontal cortex recruitment by risky rewards. Journal of Neuroscience. 2007 May 2;27(18):4839-49. PubMed
Schottenbauer MA, Momenan R, Kerich M, Hommer DW. Relationships among aging, IQ, and intracranial volume in alcoholics and control subjects. Neuropsychology. 2007 May;21(3):337-45. PubMed
Bjork JM, Hommer DW. Anticipating instrumentally obtained and passively-received rewards: A factorial fMRI investigation. Behavioural Brain Research. 2007 Feb 12;177(1):165-70. PubMed
Brown AK, George DT, Fujita M, Liow J, Ghose S, Sangare J, Hommer DW, Innis RB. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcoholism: Clinical and Experimental Research. 2007 Jan;31(1):28-32. PubMed
Rio DE, Rawlings RR, Woltz LA, Salloum JB, Hommer DW. Single subject image analysis using complex general linear model - An application to functional magnetic imaging with multiple inputs. Computer Methods and Programs in Biomedicine. 2006 Apr;82(1):10-9. PubMed
Bjork JM, Hommer DW, Grant SJ, Danube C. Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. Alcohol. 2004 Oct-Nov;34(2-3):133-50. PubMed
Knutson B, Bjork JM, Fong GW, Hommer D, Mattay VS, Weinberger DR. Amphetamine modulates human incentive processing. Neuron. 2004 Jul 22;43(2):261-9. PubMed
Momenan R, Rawlings R, Fong G, Knutson B, Hommer D. Voxel-based homogeneity probability maps of gray matter in groups: assessing the reliability of functional effects. Neuroimage. 2004 Mar;21(3):965-72. PubMed
Bjork JM, Knutson B, Fong GW, Caggiano DM, Bennett SM, Hommer DW. Incentive-elicited brain activation in adolescents: similarities and differences from young adults. J Neurosci. 2004 Feb;24(8):1793-802. PubMed
Bjork JM, Grant SJ, Hommer DW. Cross-sectional volumetric analysis of brain atrophy in alcohol dependence: effects of drinking history and comorbid substance use disorder. Am J Psychiatry. 2003 Nov;160(11):2038-45. PubMed
REVIEWS AND BOOK CHAPTERS
Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Le, AD, Hipskind, PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh, J, Tauscher JT, Hunt SP, Hommer, D, Heilig M: Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol. 2009 Nov;43:491-8. PubMed
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