Selected Publications

Search for all publications from the Alvarez Lab on PubMed

A. Matsui, V.A. Alvarez (2018) Cocaine inhibition of synaptic transmission in the ventral pallidum is pathway-specific and medidated by serotonin. Cell Report 23(13), 3852–3863.

K.H. LeBlanc, T.D. London, I. Szczot, M.E. Bocarsly, D.M. Friend, K.P. Nguygen, M.M. Mengesha, M. Rubenstein, V.A. Alvarez, A.V. Kravitz (2018) Striatopallidal neurons control avoidance behavior in exploratory tasks. Molecular Psychiatry (epub ahead of print doi:10.1038/s41380-018-0051-3).

D.M. Friend, K. Devarakonda, T.J. O'Neal, M. Skirzewski, I. Papazoglou, A. Kaplan, J.S.Liow, S.G. Rane, M. Rubenstein, V.A. Alvarez, K.D. Hall, A.V. Kravitz. (2018) Basal ganglia dysfunction contributes to physical inactivity in obesity. Cell Metabolism 25(2), 312–321.

D.M. Lovinger, V.A. Alvarez (2017) Alcohol and basal ganglia circuitry: Animal models. Neuropharmacology 122, 46–55.

A. Matsui, V.A. Alvarez (2017) Undercover Power of Endocannabinoids: Postsynaptic Ion-Channel Modulator. Neuron 93(6), 1243–1244.

M.A. Hutchison, X. Gu, M.F. Adrover, M.R. Lee, T.S. Hnasko, V.A. Alvarez, W. Lu (2017) Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Mol. Psychiatry advanced online publication 14 February 2017; doi:10.1038/mp.2017.7.

P. Charbogne, O. Gardon, E. Martín-García, H.L. Keyworth, A. Matsui, A.E. Mechling, T. Bienert, T. Nasseef, A. Robé, L. Moquin, E. Darcq, S. Ben Hamida, P. Robledo, A. Matifas, K. Befort, C. Gavériaux-Ruff, L.A. Harsan, D. von Elverfeldt, J. Hennig, A. Gratton, I. Kitchen, A. Bailey, V.A. Alvarez, R. Maldoado, B.L. Kiefer (2017) Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food. Biol. Psychiatry 81(9):778–788.

D.M. Friend, K. Devarakonda, T.J. O'Neal, M. Skirzewski, I. Papazoglou, A.R. Kaplan, J.S. Liow, J. Guo, S.G. Rane, M. Rubenstein, V.A. Alvarez, K.D. Hall, A.V. Kravitz (2017) Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity. Cell Metab. 25(2), 312–21.

L.K Dobbs, J.C. Lemos, V.A. Alvarez (2017) Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders. Genes Brain Behav. 16(1), 56–70.

J.C. Lemos, D.M. Friend, A.R. Kaplan, J.H. Shin, M. Rubenstein, A.V. Kravitz, V.A. Alvarez (2016) Enhanced GABA Transmission Drives Bradykinesia Following Loss of Dopamine D2 Receptor Signaling. Neuron 90(4), 824–38.

L.K Dobbs, A.R. Kaplan, J.C. Lemos, A. Matsui, M. Rubenstein, V.A. Alvarez (2016) Dopamine Regulation Lateral Inhibition between Striatal Neurons Gates the Stimulant Actions of Cocaine. Neuron 90(5), 1100–13.

V.A. Alvarez (2016) Clues on the coding of reward cues by the nucleus accumbens. PNAS USA 113(10, 2560–2.

J.H. Shin, M.F. Adrover, J. Wess, V.A. Alvarez (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. PNAS USA 112(26), 8124–9.

K.B. Holroyd, M.F. Adrover, R.L. Fuino, R. Bock, A.R. Kaplan, C.M. Gremel, M. Rubinstein, V.A. Alvarez (2015). Loss of feedback inhibition via D2 autoreceptors enhances acquistion of cocaine taking and reactivity to drug-paired cues. Neurophsychopharm advanced online publication 21 January 2015; doi: 10.1038/npp.2014.336.

M.F. Adrover, J.H. Shin, and V.A. Alvarez (2014). Glutamate and dopamine transmission from midbrain dopamine neurons share similar release properties but are differentially affected by cocaine. J. Neurosci. 34 (9), 3183–3192.

C. Cui, A. Noronha, H. Morikawa, V.A. Alvarez, G.D. Stuber, K.K. Szumlinski, T.L. Kash, M. Roberto, and M.V. Wilcox (2013). New insights on neurobiological mechanisms underlying alcohol addiction. Neuropharmacology 67:223–232.

M.V. Wilcox, V.C. Cuzon Carlson, N. Sherazee, G.M. Sprow, R. Bock, T.E. Thiele, D.M. Lovinger, and V.A. Alvarez (2014). Repeated binge-like ethanol drinking alters ethanol drinking patterns and depresses striatal GABAergic transmission. Neuropsychopharmacology 39(3):579–594.

R. Bock, J.H. Shin, A.R. Kaplan, A. Dobi, E. Markey, P.F. Kramer, C.M. Gremel, C.H. Christensen, M.F. Adrover, and V.A. Alvarez (2013). Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nat. Neurosci. 16(5):632–638.

N. Sherazee, V.A. Alvarez (2013). DiOlistics: delivery of fluorescent dyes into cells. Methods Mol. Biol. 940:391–400.

A. Dobi, G.K. Seabold, C.H. Christensen, R. Bock, and V.A. Alvarez. (2011). Cocaine-Induced Plasticity in the Nucleus Accumbens Is Cell Specific and Develops without Prolonged Withdrawal. J. Neurosci. 31:1895–904.

P.F. Kramer, C.H. Christensen, L.A. Hazelwood, A. Dobi, R. Bock, D.R. Sibley, Y. Mateo, and V.A. Alvarez. (2011). Dopamine D2 receptor overexpression alters behavior and phsiology in Drd2-EGPFP mice. J. Neurosci. 31:126–32. Faculty of 1000 "Recommended" list.

E. Bello Gay, Y. Mateo, D.M. Gelman, D. Noaín, J.H. Shin, C.M. Bäckman, M.J. Low, V.A. Alvarez, D.M. Lovinger and M. Rubinstein (2011). Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nature Neurosci. 14: 1033–8

V. Cuzon Carlson, G.K. Seabold, C.M. Helms, N. Garg, M. Odagiri, A.R. Rau, J. Daunais, and V.A. Alvarez, D.M. Lovinger and K.A. Grant (2011). Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates. Neuropsychopharm. 36: 2513–28

B.N. Mathur, N.A. Capik, V.A. Alvarez, and D.M. Lovinger (2011). Serotonin induces long-term depression at corticostriatal synapses. J Neurosci. 31(20):7402–11.

M. Feyder, R.M. Karlsson, P. Mathur, M. Lyman, R. Bock, R. Momenan, J. Munasinghe, M.L. Scattoni, J. Ihne, M. Camp, C. Graybeal, D. Strathdee, V.A. Alvarez, P. Kirsch, M. Rietschel, S. Cichon, H. Walter, A. Meyer-Lichtenberg, S.G. Grant and A. Holmes. (2010). Association of mouse Dlg4 (PSD-95) gene deletion and human DLG4 gene variation with phenotypes relevant to autism spectrum disorders and Williams' syndrome. Am. J. Psychiatry 167:1508–17.

G.K. Seabold, J.B. Daunais, A. Rau, K.A. Grant, V.A. Alvarez. (2010). DiOLISTIC labeling of neurons from rodent and non-human primate brain slices. J. Vis. Exp. (41) pii:2081.

J.L. Brigman, T. Wright, G. Talani, S. Prasad-Mulcare, S. Jinde, G.K. Seabold, P. Mathur, M.I. Davis, R. Bock, R.M. Gustin, R.J. Colbran, V.A. Alvarez, K. Nakazawa, E. Delphire, D.M. Lovinger and A. Holmes. (2010). Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J. Neurosci. 30:4590–600.

J. Cheng, X. Zhou, E.L. Miller, V.A. Alvarez, B.L. Sabatini, S.T. Wong. (2010). Oriented Markov random field based dendritic spine segmentation for fluorescence microscopy images. Neuroinformatics 8(3):157–70.

V.A. Alvarez , D.A. Ridenour and B.L. Sabatini. (2007). Distinct Structural and Ionotropic Roles of NMDA Receptors in Controlling Spine and Synapse Stability. J. Neurosci. 28:7365–76.

V.A. Alvarez and B.L. Sabatini. (2007) Anatomical and physiological plasticity of dendritic spines. Annu. Rev. Neurosci. 30:79–97.

V.A. Alvarez , D.A. Ridenour and B.L. Sabatini. (2006). Retraction of synapses and dendritic spines induced by off-target effects of RNA interference. J. Neurosci. 26:7820–5. Faculty of 1000 "Must Read" list.

S.F. Tavazoie*, V.A. Alvarez* , D.A. Ridenour, D.J. Kwiatkowski, B.L. Sabatini (2005). Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci. 8, 1727–34. Faculty of 1000 "Recommended" list.

V.A. Alvarez , C. Chow, E.J. Van Bockstaele and J.T. Williams. (2002). Frequency-dependent synchronization of locus coeruleus neurons: role of electrotonic coupling. Proc Natl Acad Sci U S A . 99: 4032–6.

V.A. Alvarez *, S. Arttamangkul*, J. Whistler, M. van Zastrow, D. Grandy and J.T. Williams. (2002). mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization. J Neurosci. 22: 5769–76.

V.A. Alvarez , S. Arttamangkul, and J.T. Williams. (2001). A RAVE about Opioid Withdrawal. Neuron 32: 761–763. New and Views.

V.A. Alvarez , Maubecin, F. Garcia-Hernandez, J.T. Williams and E. Van Bockstaele. (2000). Functional coupling between neurons and glia. J. Neurosci. 20: 4091–4098.