Laboratory of Cardiovascular Physiology and Tissue Injury

Contact Information

  • Office: (301) 443-4830
  • Fax: (301) 480.0257

Overview of the Lab

The Laboratory of Cardiovascular Physiology and Tissue Injury (LCPTI) seeks to understand the cellular and molecular mechanisms of the complex interplay of oxidative/nitrative stress, inflammation, lipid signaling (for example endocannabinoid signaling) and cell death pathways (e.g. poly(ADP)-ribose polymerase) in tissue injury, and to identify new therapeutic targets using clinically relevant animal models of disease (e.g., ischemia reperfusion injury, cardiomyopathies/heart failure, nephropathies, cardiovascular aging, and alcohol induced cardiovascular, liver and kidney injury and neuroinflammation).

View Dr. Pacher's Curriculum Vitae

Lab Members

Selected Publications

(from over 300; to access all publications from Dr. Pacher, please click here.

Cinar R, Iyer MR, Liu Z, Cao Z, Jourdan T, Erdelyi K, Godlewski G, Szanda G, Liu J, Park JK, Mukhopadhyay B, Rosenberg AZ, Liow JS, Lorenz RG, Pacher P, Innis RB, Kunos G. Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis. JCI Insight. 2016 Jul 21;1(11). pii: e87336. PubMed

Matyas C, Varga ZV, Mukhopadhyay P, Paloczi J, Lajtos T, Erdelyi K, Nemeth BT, Nan M, Hasko G, Gao B, Pacher P. Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction, and steatosis. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1658-70. doi: 10.1152/ajpheart.00214.2016. PubMed

Antonioli L, Yegutkin GG, Pacher P, Blandizzi C, Haskó G. Anti-CD73 in cancer immunotherapy: awakening new opportunities. Trends Cancer. 2016 Feb 1;2(2):95-109. PubMed

Lee WS, Erdelyi K, Matyas C, Mukhopadhyay P, Varga ZV, Liaudet L, Haskó G, Čiháková D, Mechoulam R, Pacher P. Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. Mol Med. 2016 Jan 8. doi: 10.2119/molmed.2016.00007. PubMed

Bronova I, Smith B, Aydogan B, Weichselbaum RR, Vemuri K, Erdelyi K, Makriyannis A, Pacher P, Berdyshev EV. Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1. Am J Respir Cell Mol Biol. 2015 Oct;53(4):555-62. doi: 10.1165/rcmb.2014-0331OC. PubMed

Mukhopadhyay P, Baggelaar M, Erdelyi K, Cao Z, Cinar R, Fezza F, Ignatowska-Janlowska B, Wilkerson J, van Gils N, Hansen T, Ruben M, Soethoudt M, Heitman L, Kunos G, Maccarrone M, Lichtman A, Pacher P, Van der Stelt M. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. Br J Pharmacol. 2016 Feb;173(3):446-58. doi: 10.1111/bph.13338. PubMed

Varga ZV, Ferdinandy P, Liaudet L, Pacher P. Drug-induced mitochondrial dysfunction and cardiotoxicity. Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1453-67. doi: 10.1152/ajpheart.00554.2015. PubMed

Xu MJ, Cai Y, Wang H, Altamirano J, Chang B, Bertola A, Odena G, Lu J, Tanaka N, Matsusue K, Matsubara T, Mukhopadhyay P, Kimura S, Pacher P, Gonzalez FJ, Bataller R, Gao B. Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. Gastroenterology. 2015 Oct;149(4):1030-41.e6. doi: 10.1053/j.gastro.2015.06.009. PubMed

Gruden G, Barutta F, Kunos G, Pacher P. Role of the endocannabinoid system in diabetes and diabetic complications. Br J Pharmacol. 2016 Apr;173(7):1116-27. doi: 10.1111/bph.13226. PubMed

Maccarrone M, Bab I, Bíró T, Cabral GA, Dey SK, Di Marzo V, Konje JC, Kunos G, Mechoulam R, Pacher P, Sharkey KA, Zimmer A. Endocannabinoid signaling at the periphery: 50 years after THC. Trends Pharmacol Sci. 2015 May;36(5):277-96. doi: 10.1016/ PubMed

Antonioli L, Blandizzi C, Csóka B, Pacher P, Haskó G. Adenosine signalling in diabetes mellitus--pathophysiology and therapeutic considerations. Nat Rev Endocrinol. 2015 Apr;11(4):228-41. doi: 10.1038/nrendo.2015.10. PubMed

Hao E, Mukhopadhyay P, Cao Z, Erdélyi K, Holovac E, Liaudet L, Lee WS, Haskó G, Mechoulam R, Pacher P. Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis. Mol Med. 2015 Jan 6;21:38-45. doi: 10.2119/molmed.2014.00261. PubMed

Lugrin J, Parapanov R, Rosenblatt-Velin N, Rignault-Clerc S, Feihl F, Waeber B, Müller O, Vergely C, Zeller M, Tardivel A, Schneider P, Pacher P, Liaudet L. Cutting edge: IL-1α is a crucial danger signal triggering acute myocardial inflammation during myocardial infarction. J Immunol. 2015 Jan 15;194(2):499-503. doi: 10.4049/jimmunol.1401948. PubMed

Bai P, Nagy L, Fodor T, Liaudet L, Pacher P. Poly(ADP-ribose) polymerases as modulators of mitochondrial activity. Trends Endocrinol Metab. 2015 Feb;26(2):75-83. doi: 10.1016/j.tem.2014.11.003. PubMed

Steffens S, Pacher P. The activated endocannabinoid system in atherosclerosis: driving force or protective mechanism? Curr Drug Targets. 2015;16(4):334-41. PubMed

Jourdan T, Szanda G, Rosenberg AZ, Tam J, Earley BJ, Godlewski G, Cinar R, Liu Z, Liu J, Ju C, Pacher P, Kunos G. Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5420-8. doi: 10.1073/pnas.1419901111. PubMed

Csóka B, Németh ZH, Törő G, Koscsó B, Kókai E, Robson SC, Enjyoji K, Rolandelli RH, Erdélyi K, Pacher P, Haskó G. CD39 improves survival in microbial sepsis by attenuating systemic inflammation. FASEB J. 2015 Jan;29(1):25-36. doi: 10.1096/fj.14-253567. PubMed

Varga ZV, Giricz Z, Liaudet L, Haskó G, Ferdinandy P, Pacher P. Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochim Biophys Acta. 2015 Feb;1852(2):232-42. doi: 10.1016/j.bbadis.2014.06.030. PubMed

Antonioli L, Blandizzi C, Pacher P, Haskó G. Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer. 2013 Dec;13(12):842-57. doi: 10.1038/nrc3613. PubMed

Csóka B, Koscsó B, Töro G, Kókai E, Virág L, Németh ZH, Pacher P, Bai P, Haskó G. A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Diabetes. 2014 Mar;63(3):850-66. doi: 10.2337/db13-0573. PubMed

Mukhopadhyay P, Rajesh M, Cao Z, Horváth B, Park O, Wang H, Erdelyi K, Holovac E, Wang Y, Liaudet L, Hamdaoui N, Lafdil F, Haskó G, Szabo C, Boulares AH, Gao B, Pacher P. Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis. Hepatology. 2014 May;59(5):1998-2009. doi: 10.1002/hep.26763. PubMed

Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Pacher P, Persidsky Y. Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier. Am J Pathol. 2013 Nov;183(5):1548-58. doi: 10.1016/j.ajpath.2013.07.033. PubMed

Pacher P, Kunos G. Modulating the endocannabinoid system in human health and disease--successes and failures. FEBS J. 2013 May;280(9):1918-43. doi: 10.1111/febs.12260. PubMed

Cao Z, Mulvihill MM, Mukhopadhyay P, Xu H, Erdélyi K, Hao E, Holovac E, Haskó G, Cravatt BF, Nomura DK, Pacher P. Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice. Gastroenterology. 2013 Apr;144(4):808-817.e15. doi: 10.1053/j.gastro.2012.12.028. PubMed

Silverman MN, Mukhopadhyay P, Belyavskaya E, Tonelli LH, Revenis BD, Doran JH, Ballard BE, Tam J, Pacher P, Sternberg EM. Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice. Mol Psychiatry. 2013 Sep;18(9):1006-17. doi: 10.1038/mp.2012.131. PubMed

Szabo C, Pacher P. The outsiders: emerging roles of ectonucleotidases in inflammation. Sci Transl Med. 2012 Aug 8;4(146):146ps14. doi:10.1126/scitranslmed.3004378. PubMed

Mukhopadhyay P, Horváth B, Zsengellėr Z, Bátkai S, Cao Z, Kechrid M, Holovac E, Erdėlyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants. Free Radic Biol Med. 2012 Sep 1;53(5):1123-38. doi: 10.1016/j.freeradbiomed.2012.05.036. PubMed

Steffens S, Pacher P. Targeting cannabinoid receptor CB(2) in cardiovascular disorders: promises and controversies. Br J Pharmacol. 2012 Sep;167(2):313-23. doi: 10.1111/j.1476-5381.2012.02042.x. PubMed

Rajesh M, Bátkai S, Kechrid M, Mukhopadhyay P, Lee WS, Horváth B, Holovac E, Cinar R, Liaudet L, Mackie K, Haskó G, Pacher P. Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. Diabetes. 2012 Mar;61(3):716-27. doi: 10.2337/db11-0477. PubMed

B Horvath, P Mukhopadhyay, G Hasko, P Pacher. The endocannabinoid system: plant-derived cannabinoids in diabetes and diabetic complications. Am J Pathology 2012 Feb;180(2):432-42 PubMed

G Hasko, P Pacher. Regulation of macrophage function by adenosine. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):865-9 PubMed

B Horvath, P Mukhopadhyay, M Kechrid, V Patel, G Tanashian, DA Wink, J Gertsch, P Pacher. β-caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor dependent manner. Free Radic Biol Med. 2012 Apr 15;52(8):1325-33. PubMed

P Mukhopadhyay, B Horváth, Z Zsengellér, J Zielonka, G Tanchian, E Holovac, M Kechrid, V Patel, IE Stillman, SM Parikh, J Joseph, B Kalyanaraman, P Pacher. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med. 2012 Jan 15;52(2):497-506. PubMed

P Mukhopadhyay, B Horváth, M Rajesh, S Matsumoto, K Saito, S Bátkai, V Patel, G Tanchian, RY Gao, BF Cravatt, G Haskó, P Pacher. Fatty acid amide hydrolase is a key regulator of the endocannabinoid-induced myocardial tissue injury. Free Radic Biol Med. 2011;50(1):179-95. PubMed

P Mukhopadhyay, B Horváth, M Kechrid, G Tanchian, M Rajesh, AS Naura, AH Boulares, P Pacher. 2. Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury. Free Radic Biol Med. 2011 Nov 1;51(9):1774-88. [Epub ahead of print]. PubMed
P Mukhopadhyay, M  Rajesh, B Horváth, S Bátkai, O Park, O Tanashian, RY Gao, V Patel, DA Wink, L Liaudet, G Haskó, R Mechoulam, P Pacher. Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death. Free Radic Biol Med. 2011 50(10):1368-81. PubMed

B Horvath, L Magid, M Partha, B Sandor, M Rajesh, O Park, G Tanchian, R Gao, C Goodfellow, M Glass, R Mechoulam, P Pacher. A new cannabinoid 2 receptor agonist HU-910 attenuates oxidative stress, inflammation, and cell death associated with hepatic ischemia/reperfusion injury. Br J Pharmacol. 2012 Apr;165 (8):2462-2478. PubMed

J-P Stasch, P Pacher, Evgenov O. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary diseases. Circulation 2011;123(20):2263-73.  PubMed

B Csóka, Z Selmeczy, B Koscsó, ZH Németh, P Pacher, PJ Murray, D Kepka-Lenhart, SM. Morris, Jr., WC Gause, SJ Leibovich, and G Haskó. Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J. 2012 Jan;26(1):376-86. PubMed

Csóka B, Németh ZH, Rosenberger P, Eltzschig HK, Spolarics Z, Pacher P, Selmeczy Z, Koscsó B, Himer L, Vizi ES, Blackburn MR, Deitch EA, Haskó G. A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation. J Immunol. 2010 Jul 1;185(1):542-50. PubMed

N Horiguchi, M Andrew, W Hua, F Lafdil, M Rajesh, P Mukhopadhyay, P Ogyi,  P Pacher, B Gao. Dissociation of liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific STAT3 knockout mice. Hepatology 2010, May;51(5):1724-34. PubMed
N Loukili, N Rosenblatt-Velin N, J Rolli, S Levrand, F Feihl, B Waeber, P Pacher, L Liaudet. Oxidants positively or negatively regulate nuclear factor kappa B in a context-dependent manner. J Biol Chem. May 21;285(21):15746-52. PubMed

P Mukhopadhyay, H Pan, M Rajesh, S Bátkai, V Patel, J Harvey-White, B Mukhopadhyay, G Haskó, B Gao, K Mackie, P Pacher. CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model. Br J Pharmacol 2010 Jun;160(3):657-68. PubMed

M Rajesh, P Mukhopadhyay, G Haskó, L Liaudet, K Mackie, P Pacher. Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent MAPK activation and cell death in human coronary artery endothelial cells. Br J Pharmacol 2010 Jun;160(3):688-700. PubMed

Pan H, Mukhopadhyay P, Rajesh M, Patel V, Mukhopadhyay B, Gao B, Hasko G, P Pacher. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation and cell death. J Pharmacol Exp Ther. 2009; 328(3):708-14. PubMed

P Mukhopadhyay, Rajesh M, S Bátkai, K Yoshihiro, G Haskó, L Liaudet, C Szabó and P Pacher. Role of superoxide, nitric oxide and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1466-83. PubMed
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P Pacher, Steffens S. The emerging role of the endocannabinoid system in cardiovascular disease. Semin Immunopathol. 2009 Jun;31(1):63-77. PubMed

Biro T, Toth BI, Hasko G, Paus R, P Pacher. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. Trends in Pharmacological Science  2009;30(8):411-20 (Cover highlight). PubMed

G Hasko, B Csoka, ZH Nemeth, ES Vizi, and  P Pacher. A2B adenosine receptors in immunity and inflammation. Trends in Immunology 2009 Jun;30(6):263-70. PubMed

N Horiguchi, L Wang, P Mukhopadhyay, O Park, WI Jeong, F Lafdil, D Osei-Hyiaman, A Moh, XY Fu, P Pacher, G Kunos, B Gao. Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology. 2008;134(4):1148-58. PubMed

Rajesh M, Mukhopadhyay P, Haskó G, Huffman JW, Mackie K, P Pacher. CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration. Br J Pharmacol. 2008;153(2):347-57. PubMed

KH Moon, BL Hood, P Mukhopadhyay, R Mohanraj, MA Abdelmegeed, YI Kwon, TP Conrads, TD Veenstra, BJ Song, P Pacher. Oxidative Inactivation of Key Mitochondrial Proteins Leads to Dysfunction and Injury in Hepatic Ischemia Reperfusion.Gastroenterology. 2008;135(4):1344-57.  PubMed

Haskó G, P Pacher. A2A receptors in inflammation and injury: lessons learned from transgenic animals. J Leukoc Biol. 2008;83(3):447-55.  PubMed

P Pacher, Haskó G. Endocannabinoids and cannabinoid receptors in ischaemia-reperfusion injury and preconditioning. Br J Pharmacol. 2008;153(2):252-62.  PubMed

P Pacher, P Mukhopadhyay, M Rajesh, S Bátkai, G Kunos. Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential. Hypertension 2008 Oct;52(4):601-7.  PubMed

 P Pacher, C Szabo. Role of peroxynitrite and PARP in human diseases. Am J Pathology. 2008;173(1):2-13. PubMed

G Hasko, J Linden, B Cronstein, P Pacher. Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nature Reviews Drug Discovery 2008 Sep;7(9):759-70. PubMed

N Agarwal, P Pacher, F Amaya, C Constantin, G Brenner, C Michalski,  I Tegeder, G Marsicano, C Marian, S Batkai, MJ Fischer, P Reeh, G. Kunos, B Lutz, M Kress, C J Woolf, R Kuner. Cannabinoids induce analgesia primarily via CB1 receptors on peripheral nociceptive neurons. Nature Neurosci. 2007;10(7):870-9. PubMed

B Csóka, ZH Nemeth, L Virag, P Gergely, SJ Leibovich, P Pacher, ES Vizi, EA Deitch, G Hasko. Adenosine receptor activation ameliorates type 1 diabetes. A2A adenosine receptors and C/EBPbeta are crutially required for IL-10 production by macrophages exposed to E. coli. Blood 2007; 110(7):2685-95. PubMed

ZH Nemeth, D Bleich, B Csóka, P Pacher, JG Mabley, ES Vizi, EA Deitch, C Szabo, G Hasko. Adenosine receptor activation ameliorates type 1 diabetes. FASEB J. 2007; 21:2379-2388.   PubMed

CW Michalski, T Laukert, P Pacher, N Agarwal, F Bergmann, Y Su, S Bátkai, H Friess and R Kuner. Cannabinoids ameliorate pain and reduce disease pathology in acute pancreatitis in the absence of central side-effects. Gastroenterology 2007;132(5):1968-78. PubMed

M Rajesh, P Mukhopadhyay, S Batkai, G Hasko, L Liaudet, JW Huffman, A Csiszar, ZI Ungvari, K Mackie, S Chatterjee, and P Pacher. Cannabinoid-2 receptor stimulation attenuates TNF -induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol Heart Circ Physiol, 2007;293(4):H2210-8. PubMed

M Rajesh, H Pan, P Mukhopadhyay, S Bátkai, D Osei-Hyiaman, G Haskó, L Liaudet, B Gao, P P Pacher. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response and apoptosis. Journal of Leukocyte Biology 2007;82(6):1382-9. PubMed
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P Mukhopadhyay, M Rajesh, G Haskó, BJ. Hawkins, Madesh M, P Pacher. Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nature Protocols 2007;2(9):2295-301.  PubMed

Milman G, Maor Y, Abu-Lafi S, Horowitz M, Gallily R, Batkai S, Mo FM, Offertaler L, P Pacher, Kunos G, Mechoulam R. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proc Natl Acad Sci U S A. 2006;103(7):2428-33. PubMed

ZH Németh, B Csóka, J Wilmanski, D Xu, Q Lu, C Ledent, EA Deitch, P Pacher, Z Spolarics, and G Haskó. Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. J Immunol 2006; 176(9):5616-5626.  PubMed

M Blüher, S Engeli, N Klöting, J Berndt, M Fasshauer,  S Bátkai, P Pacher, MR Schön, J Jordan, M Stumvoll. Dysregulation of the Peripheral and Adipose-Tissue Endocannabinoid System in Human Abdominal Obesity Diabetes 2006;55(11):3053-60.  PubMed

O Ilnytska, VV Luzogubov, MJ Stevens, VR Drel, N Mashtalir, P Pacher, MA Yorek, IG Obrosova. Poly(ADP-ribose) polymerase inhibition alleviates experimental sensory neuropathy. Diabetes; 55(6):1686-1694. PubMed

O Evgenov, P Pacher, PM Schmidt, G Hasko, HW Schmidt, J-P Stasch. Nitric-oxide independent stimulators of soluble guanylate cyclase: Development and therapeutic potential. Nature Reviews Drug Discovery 2006;5(9):755-768. PubMed

P Pacher, A Nivorozhkin, C Szabo. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacological Reviews 2006;58:87-114. PubMed

D Osei-Hyiaman, M DiPetrillo, P Pacher, S Radaeva, J Liu, J Harwey-W, S Batkai,L Offertaler, G Kunos. "Cannabinoid Regulation of Fatty Acid Synthesis. Links Peripheral Metabolic and Central Appetitive Mechanisms. JCI 2005;115(5):1298-1305. PubMed

IG Obrosova, VR Drel, P Pacher, O Ilnytska, ZQ Wang, MJ Stevens, MA Yorek. Oxidative-nitrosative stress and PARP activation in experimental diabetic neuropathy: the relation is revisited.  Diabetes 2005;54(12):3435-4341. PubMed

S Engeli, J Böhnke, M Feldpausch, K Gorzelniak, J Janke, S Bátkai, P Pacher, FC Luft, AM Sharma, J Jordan. Activation of the Peripheral Endocannabinoid System in Human Obesity. Diabetes. 2005;54(10):2838-2843. PubMed

Z Nemeth, CS Lutz, B Csoka, EA Deitch, SJ Leibovich, WC Gause, M Tone, P Pacher, ES Vizi, G Hasko. Adenosine augments interleukin-10 production by macrophages through an A2B receptor-mediated post-transcriptional mechanism. J Immunulogy 2005;175(12):8260-70. PubMed

IG Obrosova, P Pacher, C Szabo, Z Zsengeller, H Hirooka, MJ Stevens, MA Yorek. Aldose Reductase Inhibition Counteracts Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase Activation in Tissue Sites for Diabetes Complications. Diabetes. 2005;54(1):234-242. PubMed

P Pacher & C Szabó. Role of poly(ADP-ribose) polymerase-1 (PARP)  activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme. Antioxidants & Redox Signaling 2005;7(11-12):1568-80. PubMed

P Pacher, I Obrosova, JG Mabley & C Szabó. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications.  Emerging new therapeutical strategies Curr Med Chem 2005;12(3):267-275. PubMed

P Pacher, R Shultz, L Liaudet, C Szabo. Nitrosative stress and pharmacological modulation of heart failure. Trends in Pharmacological Sciences 2005;26(6):302-310.  PubMed

S Batkai, P Pacher, D Osei-Hyiaman, S Radaeva, J Liu, J Harwey-W, L Offertaler, K Mackie, MA Rudd, R Bukoski, G Kunos. Endocannabinoids acting at CB1 receptors tonically regulate cardiovascular function in hypertension. Circulation 2004;110(14):1996-2002.  PubMed

Kunos G, Pacher P. Cannabinoids cool the intestine. Nature Medicine. 2004 Jul;10(7):678-9. PubMed

P Pacher, JG. Mabley, L Liaudet, A Marton, G Hasko, O Evgenov, M Kollai and C Szabó. Left ventricular pressure-volume relationship in a rat model of advanced aging-induced heart failure. Am J Physiol Heart Circulation Physiol 2004;287(5):H2132-2137. PubMed

P Pacher, A Vasslin, R Benkõ, JG Mabley, L Liaudet, G Hasko, S Batkai, A Marton, M Kollai, and C Szabo. A novel ultrapotent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging. JPET 2004;311(2):485-491.  PubMed

P Pacher, L Liaudet, P Bai, J G. Mabley, P Kaminski, L Virág, É Szabó, Z Ungvari, MS Wollin, JT Groves, C Szabó. A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 2003;107(6):896-904. PubMed

P Pacher, L Liaudet, JG Mabley, C Szabó. Pharmacological inhibition of poly(ADP-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure. JACC 2002, 40/5: 1006-1016.  PubMed

P Pacher, L Liaudet, FG Soriano, JG Mabley, E Szabó and C Szabó. The role of poly(ADP-ribose) polymerase in the development of cardiovascular dysfunction in diabetes mellitus. Diabetes 2002, 51:514-521. PubMed

P Pacher, AP Thomas, G Hajnoczky. Ca2+ Marks: Miniature calcium signals in single mitochondria driven by ryanodine receptors. PNAS USA, 2002, 99: 2380-2385. PubMed

G Szabó, S Bährle, N Stumpf, K Sonnenberg, É Szabó, P Pacher, T Csont, R Schulz, TJ Dengler, L Liaudet, GJ Southan, CF Vahl, S Hagl and C Szabó. Poly (ADP-ribose) Polymerase Inhibition Reduces Reperfusion Injury after Heart Transplantation. Circ Res 2002; 11;90(1):100-6.   PubMed

C Szabó, A Zanchi, K Komjáti, P Pacher, AS Krolewski, WC Quist, ES Horton, FW LoGerfo, A Veves. Poly (ADP-ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation 2002;106:2680-2686. PubMed

G Soriano, P Pacher, J Mabley, L Liaudet, C Szabo. Rapid reversal of diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 2001;89(8):684-91. PubMed

P Pacher & G Hajnoczky. Propagation of the apoptotic signal by mitochondrial waves. EMBO J 2001;20:4107-4121. PubMed

Other Lab Resources


Visiting Fellows:
- Rajesh Mohanraj Ph.D, 2006-2011, currently Assistant Professor, UAE University
- Sandor Batkai MD, PhD, 2010-2011, currently group leader, University of Hannover
- Katalin Erdelyi, PhD, 2012-2015, currently research associate at the National Institute of Oncology in Budapest, Hungary 

Guest researchers:
- Hao Pan, MD, currently nephrologist in China
- Enrique Guerrero-Beltrán, PhD, currently Postdoctoral Fellow, Universidad Nacional Autónoma de México
- Bela Horvath, MD, PhD, guest researcher (supported by Hungarian NIH), currently Pathology Resident, Cleveland Clinic
- Wen-Shin Lee, MD, 2011-2012
- Enkui Hao, MD, 2011-2012
- Zongxian Cao, MD, PhD,IRTA Fellow 2011-2014
- Yuping Wang, PhD, 2012-2013
- Lisheng Jiang, MD, 2013-2014

Summer students/special volunteers:
- Lucja Flis, Special volunteer/summer student, 2005
- Anjum Jafri, Research technician, 2005
- Nora Czifra, Student Biological Laboratory Aide, 2006
- Lauren Becker, Summer Intern, 2008
- Vivek Patel, Special volunteer/summer student (Jun 2008 till date)
- Rachael Y. Gao, Special volunteer/summer student 2009 and Summer Intern 2010
- Galin Tanchian, Special volunteer 2010 and Summer Intern 2011
- Malek Kechrid,  Student, UMBC and 2011 summer Intern
- Eileen Holovac, Special volunteer/summer student 2011-2014
- Sevil Aliyeva , MD, Special volunteer, 2014
- Csaba Matyas, MD, PhD Special volunteer, 2015-2016
- Mike Nan, Pre-Bac IRTA fellow July 2015 - July 2016


David Wink Ph.D.; Senior Investigator, NCI, Radiology Branch Contact

Murali Krishna Cherukuri Ph.D.; NCI, Radiology Branch Contact

George Kunos M.D., Ph.D.; Scientific Director, NIAAA/NIH; Contact

Byoung Song PhD; Senior Investigator, Unit of Molecular Biology, NIAAA/NIH; Contact

Esther M. Sternberg M.D., Director Integrative Neural Immune Program Section on Neuroendocrine Immunology & Behavior, NIMH/NIH; Contact

Bin Gao M.D., Ph.D; Senior Investigator, Laboratory of Liver Disease, NIAAA/NIH; Contact

Ted Usdin Ph.D.; Senior Investigator, Laboratory of Genetics, National Institute of Mental Health; Contact

Michael J. Iadarola, M.D., Ph.D., Senior Investigator, Neuronal Gene Expression Unit Pain and Neurosensory Mechanisms Branch, NIDCR

Prof. Benjamin F. Cravatt, Ph.D., Director, Departments of Cell Biology and Chemistry, The Scripps Research Institute, La Jolla, CA; USA; Contact

Daniel Nomura, Ph.D. University of California at Berkeley; Contact

Prof Ken Mackie M.D., Department of Psychological and Brain Sciences and Program in Neuroscience; Contact

Prof. Lucas Liaudet M.D., Critical Care Division, Department of Internal Medicine, University Hospital, Lausanne, Switzerland;

Prof. Csaba Szabo M.D., Ph.D.; The University of Texas Medical Branch, Galveston; Contact

Associate Prof. Zoltan Ungvari M.D., Ph.D., University of Oklahoma Health Sciences Center, USA; Contact

Prof. Irina Obrosova Ph.D.; Division of Nutrition and Chronic Disease; Pennington Biomedical Research Center; Louisiana State University, Baton Rouge, LA 70808;

Gyorgy Hasko M.D., Ph.D; Department of Surgery, UMD NJ-New Jersey Medical School, Newark, New Jersey; Contact

Prof. Rohini Kuner; University of Heidelberg, Germany; Contact

Stefan Engeli and Jens Jordan M.D., Ph.D.; University of Hannover, Germany; Contact

Sandor Batkai M.D., Ph.D., University of Hannover, Germany; Contact

Prof. Roger Pertwee Ph.D., University of Aberdeen, UK; Contact

Dr. Isaac E. Stillman MD, Department of Pathology, Beth Israel Deaconess Medical Center; Contact

Prof. Aristidis Veves M.D., Ph.D, Beth Israel Deaconess Medical Center, Boston, MA; Contact

Prof.  Aron Lichtman Ph.D., VCU; Contact

Prof. Raphael Mechoulam Ph.D.; Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty; Contact; Biography

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