The Division of Metabolism and Health Effects (DMHE) develops scientific initiatives and supports basic and translational research on the health consequences of alcohol consumption and metabolism.  The DMHE supports research on the health effects of alcohol that may result from a single dose or from chronic or binge drinking behavior emphasizing metabolic pathways, adduct formation, non-enzymatic metabolism, and various substrates that may be affected by alcohol or alcohol metabolites; genetic studies involving alcohol-metabolizing enzymes and their role in reducing risk of alcohol consumption and tissue injury; identification of molecular pathways by which alcohol causes tissue and organ damage; biomarker development to detect and monitor alcohol-induced pathologies; etiology and progression of medical disorders arising from the use of alcohol; and the use of systems biology, bioinformatics, and real-time imaging methods to uncover biological pathways and networks involved in alcohol metabolism and organ damage.

The DMHE encourages multidisciplinary approaches that integrate genetic, molecular, cellular, and animal models to understand mechanisms of alcohol action and injury.  Research areas supported by the Division include: 

  • Alcohol Metabolism and Pharmacokinetics
  • Alcohol-Induced Tissue Damage
    • Alcoholic Liver Disease
    • Alcoholic Pancreatitis
    • Alcohol and the Lung
    • Alcohol and the Cardiovascular System
    • Alcohol and Musculoskeletal Disorders
    • Biomarkers of Alcohol Use and Alcohol-induced Tissue Injury
  • Fetal Alcohol Spectrum Disorders
  • Alcohol and Cancer
  • Alcohol and the Immune System
  • Alcohol and Viral Infections
  • The Role of Mitochondria in Alcohol-induced Pathology
  • Alcohol, Retinoic Acid, and Stem Cells
  • Alcohol, Trauma, and Shock
  • Genetics, Genomics and Alcohol-induced Tissue Injury
  • Epigenetics: DNA Methylation, Histone Modification, and RNA-mediated Gene Regulation
  • Alcohol, Epigenetics, and Stem Cells
  • Systems Biology Approaches in Alcohol Research