National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Description The COMBINE Study is the largest pharmacotherapy trial conducted for Alcohol Use Disorder in the United States. This clinical trial evaluated the efficacy of naltrexone and acamprosate, both alone and in combination, in the context of medical management with and without Combined Behavioral Intervention (CBI). Study Details Sponsor: The National Institute on Alcohol Abuse and Alcoholism NCT #: 00006206...

Access to the NIAAA NESARC-III data set will only be provided to qualified research investigators who, along with their institutions, have certified their agreement with the terms of access detailed in the NIAAA NESARC-III Data Access Application and the NIAAA Data Use Agreement. Please note that review and signature from your institutional authorized signatory is required. This is ordinarily someone...

Prevalence of Underage Alcohol Use, People Ages 12 to 20 Prevalence of Lifetime Drinking According to the 2022 National Survey on Drug Use and Health (NSDUH), 13.2 million people ages 12 to 20 (34.2% in this age group) reported that they have had at least one drink in their lives. 1,2 This includes: 6.5 million males ages 12 to 20...

Scientists have identified an area within the brain’s frontal cortex that may coordinate an animal’s response to potentially traumatic situations. Understanding where and how neural circuits involving the frontal cortex regulate such functions, and how such circuits could malfunction, may provide insight about their role in trauma-related and stress-related psychiatric disorders in people. The study, led by scientists at the...

The rate of all alcohol-related emergency department visits increased 47.0% between 2006 and 2014, which translates to an average annual increase of 210,000 alcohol-related emergency department visits. 1 Estimates suggest that alcohol played a role in at least 7.1% of emergency department visits and 17.4% of deaths due to opioid overdoses in 2020. 2,3 The Alcohol-Related Disease Impact application estimates...

Description This large, multisite clinical trial evaluated the efficacy and safety of gabapentin enacarbil extended-release (GE-XR) (HORIZANT®), a gabapentin prodrug formulation for the treatment of alcohol use disorder (AUD). Study Details Sponsor: The National Institute on Alcohol Abuse and Alcoholism’s Clinical Investigations Group (NCIG) NCT #: 02252536 Phase: Phase 2 Treatment Arms: Horizant® (gabapentin enacarbil) 600mg twice a day and...

Wed, 05/15/2024 - 12:00

This article was first published in NIAAA Spectrum Volume 16, Issue 2 . Scientists at the National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified brain pathways that may coordinate an animal’s response to potentially traumatic situations. Understanding where and how neural circuits mediate such functions—and how they could malfunction—may provide clues about their role in trauma-related and stress-related...

Data Access Policy, Application and Agreement NIAAA Protocol NCIG 002: A Multisite Double-Blind, Placebo-Controlled Trial of Levetiracetam Extended-Release in Very Heavy-Drinking Alcohol-Dependent Patients Description This multisite clinical trial evaluated the efficacy and safety of levetiracetam XR, for the treatment of alcohol use disorder (AUD). Study Details Sponsor: The National Institute on Alcohol Abuse and Alcoholism’s Clinical Investigations Group (NCIG) NCT #...

Data Access Policy, Application and Agreement NIAAA Protocol NCIG 003: A Phase 2, Double-Blind, Placebo Controlled Trial to Assess the Efficacy of Varenicline Tartrate for Alcohol Dependence Description This double-blind, randomized placebo-controlled trial evaluated the efficacy and safety of varenicline tartrate for the treatment of alcohol use disorder (AUD). Study Details Sponsor: The National Institute on Alcohol Abuse and Alcoholism’s...

May 14, 2024

NIH Clinical Center Grand Rounds Genetics and Epigenetics of Alcohol Use Disorder Presenter: David Goldman, MD, Senior Investigator, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism Wednesday, May 15, 2024, 12 noon-1 p.m., live in Lipsett Auditorium and on NIH Videocast https://videocast.nih.gov/watch=54794 The lecture will be videocast at https://videocast.nih.gov/watch=54794 and archived for future viewing.  For more details or...

The National Advisory Council on Alcohol Abuse and Alcoholism advises and makes recommendations to the Secretary, HHS; the Director, NIH; and the Director, NIAAA; on research program and policy matters in the field of alcohol abuse and alcoholism. The Council comprises 18 members appointed by the Secretary and 5 nonvoting ex-officio members: the HHS Secretary; the NIH Director; the NIAAA...

Graduation is a time to celebrate. But before your high school seniors begin their parties, take the time to talk with them about keeping events alcohol-free—it just may save a life. No amount of underage drinking is legal or safe. And we know that any underage drinking can lead to consuming too much alcohol, which may result in poor decisions, injuries, alcohol overdose, and possibly death.

Summer is a wonderful time for outdoor activities with family and friends. For some people, a day at the beach, on the boat, or at a backyard barbecue will include drinking alcohol beverages. But risky drinking and summer activities don’t mix. Drinking impairs both physical and mental abilities, and it also decreases inhibitions—which can lead to tragic consequences on the water, on the road, and in the great outdoors.

May 16, 2024

The National Institute on Alcohol Abuse and Alcoholism, Division of Neuroscience and Behavior and Division of Metabolism and Health Effects will accept applications through vacancy announcement NIH-GR-DE-24-12407708 and NIH-GR-MP-24-12407723 from May 13, - May 22, 2024, at the links below. NIH-GR-MP-24-12407723 NIH-GR-DE-24-12407708 For more information visit https://www.usajobs.gov/job/790016600?PostingChannelID Health Scientist Administrator (Program Officer), Division of Neuroscience and Behavior The Division of...