National Institute on Alcohol Abuse and Alcoholism (NIAAA)
DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM AGENDA 144th Meeting of the NATIONAL ADVISORY COUNCIL ON ALCOHOL ABUSE AND ALCOHOLISM Thursday, February 9, 2017 Fishers Lane, Terrace Conference Rooms, Rockville MD 20852 11:00 AM - 3:15 PM: OPEN TO THE PUBLIC 11:00 CALL TO ORDER AND INTRODUCTIONS Dr. George Koob...
Results from a recent NIAAA study suggest that the medication ibudilast may be viable as a potential treatment for alcohol dependence. Ibudilast, an anti-inflammatory medication that acts as a non-selective phosphodiesterase inhibitor, reduces alcohol drinking and relapse in alcohol-preferring P rats, high-alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. Neuroinflammatory signaling...
Some people experience the initial effects of alcohol as stimulating and euphoric, while others experience mostly unpleasant sedative effects. How individuals’ immediate responses to alcohol influence their future drinking behavior has been an active area of scientific research. One theory holds that people who have a low level of positive response to alcohol and who also are less sensitive to...