On Thursday, June 29, 2017 the NIH SBIR/STTR Program office hosted an annual webinar to explain and discuss various aspects of the NIH SBIR/STTR Program. The 2017 Omnibus Grant Solicitations, SBIR 101, Reauthorizations, and Deadlines were addressed, with a live Question & Answer session to conclude the webinar. The slide presentation , webinar recording , and transcript are now available...
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
New research supported by NIAAA suggests that a drug currently used to prevent the rejection of transplanted organs could someday help lessen the alcohol cravings that often lead to relapse among people with drinking problems. Alcohol-related memories, or cues—such as the smell of alcohol—can trigger cue-induced alcohol craving. Previous research has found that the mammalian target of rapamycin complex 1...
The latest issue of NIAAA Spectrum is now available. In this issue: Feature "Alcohol and "Deaths of Despair" In 2015, Princeton University economists Anne Case, Ph.D., and Angus Deaton, Ph.D., reported something unexpected. After decreasing since the end of World War II, rates of death began to increase in the United States for people in some groups. The rise in...
Some people experience the initial effects of alcohol as stimulating and euphoric, while others experience mostly unpleasant sedative effects. How individuals’ immediate responses to alcohol influence their future drinking behavior has been an active area of scientific research. One theory holds that people who have a low level of positive response to alcohol and who also are less sensitive to...
The Substance Abuse Librarians and Information Specialists (SALIS), in partnership with NIAAA and a nonprofit digital library called the Internet Archive (IA), are working to digitize the literature of the alcohol-and-other-drugs field that is not already available online—specifically, books and government documents. To date, this digitization (or “Digs”) project has posted 758 items, ranging from the basic to social sciences...
You may be familiar with how doctors use pictures from magnetic resonance imaging machines, better known as MRIs, to diagnose injuries and other health problems. But did you know that NIAAA scientists have another technology that harnesses the power of strong magnets to study receptors in the brain that could be targets for alcohol therapies? NIAAA’s Intramural Section on Nuclear...
Both humans and animals experience stress. Ideally, stress serves as a survival tool, allowing organisms to adapt and overcome adversity in an unpredictable environment. As a result, higher-order animals have developed complex systems to perceive, react to, and adapt to psychological stress, ensuring that they can respond to environmental dangers that might harm or kill them. But for some, the...
An NIAAA study shows that people who drink socially and have certain risk factors for alcohol use disorder (AUD) self-administer more alcohol and at a faster rate during a single laboratory session of alcohol consumption than people at low risk for developing AUD. Participants with all three risk factors evaluated in this study—being male, having a family history of AUD...
The learning and memory disabilities associated with fetal alcohol spectrum disorder (FASD) are due, in part, to hippocampal damage caused by ethanol exposure during prenatal development. However, the mechanism by which alcohol damages the developing hippocampus remains poorly understood. In the current study, researchers examined how ethanol exposure in neonatal rats – a period that is developmentally equivalent to the...
The purpose of this notice is to inform NIH grant applicants, their mentors, and grant management officials about two online video briefings the NIH Center for Scientific Review (CSR) will host in October 2017. CSR is the portal for NIH grant applications and their review for scientific and technical merit. Each Briefing Will Have a Different Focus Getting Academic Research...
Recent NIH-wide efforts to address sex differences in preclinical research underscore the importance of such issues to scientists who study alcohol addiction. “In fact, animal models of alcohol addiction reveal significant differences between males and females,” says NIAAA Director George F. Koob, Ph.D., “but we have little data thus far to help us understand the neurobiological mechanisms for those differences.”...
Alcoholic and Nonalcoholic Steatohepatitis: Pathogenesis and Mechanisms of Liver Injury -- Joint NIAAA-NIDDK Research Specific areas of research will include hepatocyte cell injury, modes of death including apoptosis, pyroptosis, and necroptosis, injury and stress pathways, lipid synthesis and metabolism, cytokines and immune signaling, the microbiome, genetic factors, systems biology and mechanisms of the complications of chronic fatty liver. Expected Outcomes...
Adults drank more alcohol in 2012–2013 than they did in 2001–2002, according to the most recent National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). NESARC–III is a cross-sectional survey sponsored, designed, and directed by NIAAA and is the largest study ever conducted on the co-occurrence of alcohol use, drug use, and related psychiatric conditions. To assess how drinking patterns...
Two to three brief training sessions can significantly increase pediatricians’ use of screening and brief interventions to help their patients with substance use and mental health problems, according to a large, 2-year trial supported by NIAAA. The study also found that pediatric practices can increase delivery of these services by adding behavioral health clinicians to their teams. Mounting evidence supports...
Brief counseling sessions by physicians can help college students reduce harmful alcohol use, according to a new study supported by NIAAA. Led by Michael F. Fleming, M.D., M.P.H., of the University of Wisconsin, the study is part of the ongoing College Health Intervention Projects (CHIPs) study, a randomized, controlled clinical trial conducted in five college health clinics in Wisconsin, Washington...
The FOIA, 5 U.S.C. 552, provides individuals with a right to access to records in the possession of the Federal government. The government may withhold information pursuant to the nine exemptions and three exclusions contained in the Act. If you have questions regarding FOIA requests pending with NIAAA or questions specific to NIAAA records, please contact Trevor Peterson, NIAAA FOIA...