Section on Human Psychopharmacology
Division of Intramural Clinical and Biological Research
National Institute on Alcohol Abuse and Alcoholism
National Institutes of Health
10 Center Drive, Room 10-CRC/2-2352: MSC 1540
Bethesda, MD 20892-1540

 

What we do

The Section conducts studies characterizing the pharmacokinetics and CNS pharmacodynamics of alcohol in humans using behavioral, neuroendocrine, electrophysiological and functional imaging measures. These studies, conducted in social and high-risk drinkers, enable the evaluation of genetic and environmental risk factors influencing the acute and adaptive responses to alcohol. The Section is also conducting studies to develop human laboratory paradigms that can be used to screen novel potential treatments for alcoholism in terms of their ability to alter the pharmacological effects of alcohol and/or alcohol self-administration behavior.

Two alcohol administration methods form the foundation of our work: (1) the alcohol clamp, and (2) computer-assisted self-infusion of ethanol (CASE). Both methods employ intravenous (IV) administration of alcohol solutions, which when combined with a physiologically-based pharmacokinetic (PBPK) model for ethanol, results in systemic (and therefore brain) alcohol exposures that are extremely precise and well-controlled. These methods provide a unique platform for studies evaluating the influence of risk factors including sex, age, drinking history and genetic polymorphisms on alcohol responses and alcohol self-administration behavior in human laboratory studies.

Current Staff

Vijay A. Ramchandani, Ph.D.
Tenure-Track Clinical Investigator and Chief
telephone: 301-402-8527
email: 
vijay.ramchandani@mail.nih.gov

Dr. Vijay Ramchandani

Vijay Ramchandani obtained his undergraduate degree in Pharmaceutical Sciences from Bombay University in India in year 1990 and Ph.D. in Pharmaceutical Sciences from Virginia Commonwealth University, Richmond, VA in 1996. From 1996 to 2002, he worked at the Alcohol Research Center at Indiana University School of Medicine, Indianapolis, IN, first as a Research Associate and then as an Assistant Scientist and Part-time Assistant Professor. In 2003, Dr. Ramchandani joined NIAAA as a Staff Scientist in the Laboratory of Clinical and Translational Studies (LCTS), and in 2007, he became Chief of the Unit on Human Physiology and Pharmacokinetics. In March 2010, Dr. Ramchandani was appointed as a Tenure-track Clinical Investigator and Acting Chief of the Section on Human Psychopharmacology.

 

Bethany Stangl, Ph.D.
Research Fellow
telephone: 301-451-9401
email: bethany.stangl@nih.gov

Bethany Stangl, PhD

Dr. Stangl joined the Section as a postdoctoral fellow in September 2010. She earned her undergraduate degree at Dickinson College and her PhD in cognitive neuroscience at The George Washington University. She became a Research Fellow in the Section in Novem 2015. Her research uses the Computer-Assisted Self-Administration of Ethanol (CASE) protocol that uses this IV alcohol method to assess alcohol-seeking and consumption behavior that is driven primarily by the pharmacological effects of alcohol. To better characterize the motivation for alcohol, she extended this model to develop a novel progressive-ratio paradigm. Most recently her interest in the effects of stress and alcohol cues on alcohol-seeking behavior led her to develop a new method combining CASE with acute stress exposure using personalized guided imagery scripts.  Other interests include studying the relationship between childhood trauma, early life stress, genetics, and risk for substance use disorders in humans.

 

Joshua Gowin, Ph.D.
Post-Doctoral Fellow
telephone: 301-451-6968
email: joshua.gowin@nih.gov

Photo of Dr. Gowin

Dr. Gowin joined the Section in August 2013. He earned his M.S. in 2009 and his Ph.D. in 2011 in behavioral neuroscience and psychopharmacology from the University of Texas Health Science Center in Houston. While there he learned to use acute and chronic administration of drugs to examine behavioral, physiological and neuroendocrine effects. Starting in 2012, he did a one year fellowship at the University of California San Diego where he became a scan operator for fMRI studies and learned to analyze imaging data. He is interested in exploring the neural correlates of risk-taking as a lens to understand pathologic behaviors such as substance use disorders and aggression. 

 

Matthew Sloan, M.D.
Post-Doctoral Fellow
telephone: 301-827-0566
matthew.sloan@nih.gov

Matthew Sloan

Dr. Sloan joined the Section in September 2015.  He completed his medical training and Psychiatry residency at McGill University.  He is in the process of completing a Master’s Degree in Psychiatry in which his thesis project examines the effects of stressful life events and coping styles on alcohol and drug use in a cohort of young adults.  His current work includes the development of a human laboratory model to study impaired control in heavy drinkers, a PET study evaluating the effect of alcohol on the endogenous opioid system in humans, and the investigation of novel pharmacological treatment strategies for alcohol use disorder.  His clinical practice in Montreal primarily focuses on treating patients with substance use disorders and a wide range of psychiatric comorbidities. 

 

Courtney Vaughan, B.S., B.A.
Post-Baccalaureate IRTA Fellow
telephone: 301-827-8923
email: courtney.vaughan@nih.gov 

Courtney Vaughn

Courtney  Vaughan received her B.S. in Psychology and B.A. in Gender, Sexuality and Women’s Studies from Virginia Commonwealth University in May 2015, and joined the Section shortly thereafter. She is an alumna of the Undergraduate Scholarship Program (UGSP) which provides a scholarship up to $20,000 per academic year in return for a service commitment to the National Institutes of Health upon graduation. Courtney is involved in the Resist version of  the Computer-Assisted Self-Administration of Ethanol (CASE) protocol where her duties include screening participants, running experimental sessions, and administering psychological evaluations. Her research interests include  alcohol addiction, mindfulness, women’s health, and racial disparities. Courtney plans to pursue a Ph.D. in counseling or clinical psychology.

 

Alyssa Schneider, B.S.
Post-Baccalaureate IRTA Fellow
telephone: 301-827-0905
email: alyssa.schneider@nih.gov 

Alyssa Schneider

Alyssa (Allie) Schneider received her B.S. in Psychology from Allegheny College in May 2016 and joined the section shortly after graduation. She is currently working on the Nalmefene protocol where her duties include recruiting and screening participants, running experimental sessions, and analyzing participant data. Her research interests center around addiction, health disparities, and substance abuse co-occurring with psychological disorders. In the future, she plans to pursue a graduate degree in this field of study. 

 

Corbin Ester, B.S.
Post-Baccalaureate IRTA Fellow
telephone: 301-451-0308
email: corbin.ester@nih.gov 

Corbin Ester

Corbin Ester received his B.S. in Chemistry from Appalachian State University in June 2015 and joined the NCI as a CRTA. After spending a year in the Genetics Branch, he joined this section thereafter. His previous research focused on the alternative lengthening of telomeres and its role in pediatric osteosarcoma. Currently, he is assisting with the Computer-Assisted Self-Administration of Ethanol (CASE) protocol by recruiting and screening healthy volunteers, administering psychological evaluations, and running experimental sessions for the study. Corbin is interesting in understanding the role of genetics in the risk of developing psychiatric and addiction disorders. He plans to attend medical school with the goal of becoming a physician and clinical researcher.

 

Tasha Cornish, M.S.P.H.
Clinical Research Coordinator
telephone: 301-435-9397
email: tasha.cornish@nih.gov

Tasha Cornish

Tasha  joined the Section as a Clinical Research Coordinator in January 2016. As the Clinical Research Coordinator, she works closely with section staff to plan, prepare, implement, and monitor clinical research activities and she provides assistance in the writing, preparation, and submission of materials to the Institutional Review Board and the Food and Drug Administration. Tasha received her B.S. in Neuroscience from Cedar Crest College in Allentown, PA and a Master of Science in Public Health degree from the Johns Hopkins School of Public Health, where she worked on a school-based mindfulness intervention in Baltimore City Public Schools. Tasha has research interests in psychology, health equity, and research ethics.

 

Special Volunteers

Vatsalya Vatsalya, M.D. Pg.D. M.Sc. M.S.
Telephone: (502)488 0446
Email: vatsalyav@mail.nih.gov or
vatsalya.vatsalya@louisville.edu

Vatsalya Vatsalya

Dr. Vatsalya has been a Special Volunteer since February 2014, after completing his fellowship training in the Section (2009-2014). He is currently working as a research scientist with Prof. Craig McClain in the Department of Medicine at the University of Louisville School of Medicine, Louisville KY. His interests include clinical research focusing on treatment assessment, physiological and behavioral evaluations; age and sex factors; and genetic expression in alcohol pharmacology and addiction; and viral comorbidity.

 

Jia Yan, Ph.D., M.S., C.G.C.
email: jia.yan@nih.gov

Jia Yan
Dr. Yan has been a Special Volunteer since July 2015, after completing a postdoctoral fellowship in the Section. Dr. Yan obtained an M.S. in Genetic Counseling and Ph.D. in Human and Molecular Genetics through a dual degree program at Virginia Commonwealth University. Her training integrated clinical genetic counseling experience with research on alcohol dependence using statistical genetics methods at the Virginia Institute for Psychiatric and Behavioral Genetics. Her previous work investigated the use of genetic information in clinical risk prediction for alcohol dependence. Her postdoctoral work focused on the quantitative analysis of genetic and phenotypic data using genome-wide and systems-based approaches. She currently works at the Johns Hopkins University McKusick-Nathans Institute of Genetic Medicine on the clinical genetics team and is a practicing genetic counselor in the pediatric and adult medical genetics clinic. She is continuing to do research and see patients, with the aim of integrating genetic counseling and research on alcohol use disorders.

 

Joanna Sells, M.S.
joanna.sells@nih.gov

Joanna Sells
Joanna is a Medical & Clinical Psychology Ph.D. candidate at Uniformed Services University of the Health Sciences (USUHS) in Bethesda, MD.  She is completing her dissertation in collaboration with Dr. Andrew Waters (USUHS) and Dr. Vijay Ramchandani (NIAAA, SHP).  Together, they are examining the association between the ability to resist alcohol self-administration in the laboratory and the ability to abstain from drinking in the real-world using smart phones.  Joanna’s clinical training is focused on treating and assessing active duty and Veteran military populations.  Joanna is also developing her skillset in public policy, completing an internship in the Executive Office of the President, Office of National Drug Control Policy.  Previously, Joanna was a Technical IRTA at NIAAA, where she coordinated a study on the treatment of comorbid alcoholism and post-traumatic stress.  She earned her B.A. in Psychology from American University in Washington, DC and her M.S. from USUHS.  Joanna plans to use her training and experience to translate clinical insights and research findings into consumer informed public policy.

 

Section Alumni

Postdoctoral/Visiting Fellows

Vatsalya Vatsalya (2009-2014)

Jia Yan (2012-2015)

 

Postbaccalaureate/Technical IRTA (Intramural Research Training Award) Fellows

Mike Hoefer (2004-2005)

Nina Saxena (2005-2006)

Shilpa Kumar (2006-2007)

Seth Eappen (2007-2008)

Julnar Issa (2008-2010)

Megan Cooke (2009-2011)

Molly Zametkin (2010-2014)

Marion Coe (2011-2013)

Jonathan Westman (2013-2015)

Kristin Corey (2014-2015)

Lauren Blau (2014-2016)

Anuj Shah (2015-2016)

 

Summer Students/Trainees

Elizabeth Edenberg (Summer 2003)

Molly Carroll (Summer 2004)

Satjit Brar (Summer 2007)

Aishini Thiyagarajan (Summer 2008, 2009, 2010)

EB Grasser (Summer 2009)

 Elgin Yalin (Summer 2016)

 

Special Volunteers/Coordinators

Veronica Schmidt (2010-2014)

Adnan Durrani (2014-2015)

 

Nurse Trainees from Kurihama Medical and Addiction Center, Japan

Kaori Abe (Fall 2011)

Tomoko Nakao (Spring 2012)

Tohru Numano (Fall 2012)

Ryo Chinen (Fall 2013)

Haruna Kawamata (Summer/Fall 2014)

Tomoyasu Matsui (Spring/Summer 2016)

 

Protocols

08-AA-0178: Computer-Assisted Self-Administration of Ethanol (CASE) in Humans (PI: Vijay A. Ramchandani, PhD)

13-AA-0061: OPRM1 A118G SNP Effect on Striatal Dopamine Response to an IV Opiate (PI: Vijay A. Ramchandani, PhD)

16-AA-0037: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation (PI: Vijay A. Ramchandani, PhD)
 

NIAAA Clinical Protocols & link to all NIH Clinical Protocols

Selected Publications

Original Papers:

  1. Li T-K, Beard JD, Orr WE, Kwo PY, Ramchandani VA.  Gender and ethnic differences in alcohol metabolism. Alcohol Clin Exp Res 22:771-772 (1998).
  2. Kwo PY, Ramchandani VA, O'Connor S, Amann D, Carr LG, Sandrasegaran K, Kopecky K, Li T-K.  Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for lean body mass. Gastroenterology 115:1552-1557 (1998).
  3. Ramchandani VA, Bolane J, Li T-K, O'Connor S.  A physiologically-based pharmacokinetic (PBPK) model for alcohol facilitates rapid BrAC clamping. Alcohol Clin Exp Res 23:617-623 (1999).
  4. Ramchandani VA, O'Connor S, Blekher T, Kareken D, Morzorati S, Nurnberger Jr. J, Li T-K.  A preliminary study of acute responses to clamped alcohol concentration and family history of alcoholism. Alcohol Clin Exp Res 23:1320-1330 (1999).
  5. Li T-K, Beard JD, Orr WE, Kwo PY, Ramchandani VA, Thomasson HR. Variation in ethanol pharmacokinetics and perceived gender and ethnic differences in alcohol elimination. Alcohol Clin Exp Res 24:415-416 (2000).
  6. O'Connor S, Ramchandani VA Li T-K. PBPK modeling as a basis for achieving a steady BrAC of 60±5 mg% within ten minutes. Alcohol Clin Exp Res 24:426-427 (2000).
  7. Ramchandani VA, Kwo PY, Li T-K. Influence of food and food composition on alcohol elimination rates in healthy men and women. J Clin Pharmacol 41:1345-1350 (2001).
  8. Li T-K, Yin S-J, Crabb DW, O’Connor S, Ramchandani VA. Genetic and environmental influences on alcohol metabolism in humans. Alcohol Clin Exp Res 25:136-144 (2001).
  9. Sato N, Lindros KO, Baraona E, Ikejima K, Mezey E, Jarvelainen H, Ramchandani VA. Gender differences in alcohol-related organ injury. Alcohol Clin Exp Res 25:49S-53S (2001).
  10. Blekher T, Beard JD, O'Connor S, Orr WE, Ramchandani VA, Miller K, Yee RD, Li T-K. Response of saccadic eye movements to alcohol in African American and non-Hispanic White college students. Alcohol Clin Exp Res 26:232-238 (2002).
  11. Morzorati SL, Ramchandani VA, Flury L, Li T-K, O’Connor S. Self-reported subjective perception of intoxication reflects family history for alcoholism when breath alcohol levels are constant. Alcohol Clin Exp Res 26:1299-1306 (2002).
  12. Blekher T, Ramchandani VA, Flury L, Foroud T, Kareken D, Yee R, Li T-K, O’Connor S. Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol. Alcohol Clin Exp Res 26:1568-1573 (2002).
  13. Ramchandani VA, Flury L, Morzorati S, Kareken D, Blekher T, Foroud T, Li T-K, O'Connor S.  Recent Drinking History: Association with family history of alcoholism and the acute response to alcohol during a 60 mg% clamp. J Stud Alcohol 63:734-744 (2002).
  14. Morzorati SL, Ramchandani VA, Li T-K, O'Connor S. A method to achieve and maintain steady tate blood alcohol levels in rats using a physiologically-based pharmacokinetic model. Alcohol 28:189-195 (2002).
  15. Neumark YD, Friedlander Y, Durst R, Leitersdorf E, Jaffe D, Ramchandani VA, O’Connor S, Carr LG, Li T-K . Alcohol dehydrogenase (ADH2) polymorphisms influence alcohol elimination rates in a male Jewish population. Alcohol Clin Exp Res 28:10-14 (2004).
  16. Kareken DA, Claus ED, Sabri M, Dzemidzic M, Kosobud AEK, Radnovich AJ, Hector D, Ramchandani VA, O’Connor SJ, Lowe M, Li T-K. Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: Preliminary findings. Alcohol Clin Exp Res 28:550-557 (2004).
  17. Khaole NCO, Ramchandani VA, Viljoen DL, Li T-K. Systemic alcohol exposure during free-choice drinking in women with or without a child with fetal alcohol syndrome. Alcohol Alcohol 39:503-508 (2004).
  18. Plawecki MH, DeCarlo RA, Ramchandani VA, O’Connor S. Estimation of ethanol infusion profile to produce a specified BrAC time course using physiologically-based pharmacokinetic (PBPK) models. IEEE Engineering in Medicine and Biology Society International Conference Proceedings. 1:778-781 (2004).
  19. Ramchandani VA, O’Connor S, Neumark YD, Zimmermann US, Morzorati SL, de Wit H. The alcohol clamp: Applications, challenges and new Directions – An RSA 2004 symposium summary. Alcohol Clin Exp Res 30:155-164 (2006).
  20. Han J-J, Plawecki MH, Doerschuk PC, Ramchandani VA, O’Connor S. Ordinary differential equation models for ethanol pharmacokinetics based on anatomy and physiology. IEEE Engineering in Medicine and Biology Society International Conference Proceedings. (article 4029183) 1:5033-5036 (2006).
  21. Plawecki MH, DeCarlo R, Ramchandani VA, O’Connor S. Improved transformation of morphometric measurements for a priori parameter estimation in a physiologically-based pharmacokinetic model of ethanol. Biomedical Signal Processing and Control 2:97-110 (2007).
  22. Salloum JB, Ramchandani VA, Bodurka J, Rawlings R, Momenan R, George D, Hommer DW. Blunted rostral anterior cingulate response during a simplified decoding task of negative emotional facial expressions in alcoholic patients. Alcohol Clin Exp Res 31:1490-1504 (2007).
  23. Gilman J, Ramchandani VA, Davis M, Bjork JM, Hommer DW. Why we like to drink: An fMRI study of the rewarding and anxiolytic effects of alcohol. J Neurosci. 28:4583-4591 (2008).
  24. Taylor RE, Raysor BR, Kwagyan J, Ramchandani VA, Kalu N, Powell-Davis M, Ferguson CL, Carr LG, Scott DM. Alterations in ethyl alcohol pharmacokinetics during oral consumption of commercial malt liquor beverages. Alcohol Clin Exp Res 32:2074-2080 (2008).
  25. Plawecki MH, Han JJ, Doerschuk PC, Ramchandani VA, O'Connor SJ. Physiologically based pharmacokinetic (PBPK) models for ethanol. IEEE Trans Biomed Eng 55:2691-2700 (2008).
  26. Ramchandani VA, Plawecki M, Li T-K, O’Connor S. Intravenous ethanol infusions can mimic the time course of breath alcohol concentrations following oral alcohol administration in healthy volunteers. Alcohol Clin Exp Res 33:938-944 (2009).
  27. George DT, Herion D, Jones CL, Phillips MJ, Hersh J, Hill D, Heilig M,  Ramchandani VA, Geyer C, Spero DE, Singley ED, O’Malley SS, Bishai R, Rawlings RR, Kunos G. Rimonabant (SR141716) has no effect on alcohol self-administration or endocrine measures in nontreatment-seeking heavy alcohol drinkers. Psychopharmacology 208:37-44 (2010).
  28. Lee J, Ramchandani VA, Hamazaki K, Engleman EA, McBride WJ, Kim H-Y. A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats. Alcohol Clin Exp Res 34:242-250 (2010).
  29. Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M. A genetic determinant of the striatal dopamine response to alcohol. Mol Psychiatry 16:809-817 (2011).
  30. Roh S, Matsushita S, Hara S, Maesato H, Matsui T, Suzuki G, Miyakawa T, Ramchandani VA, Li T-K, Higuchi S. Role of GABRA2 in moderating subjective responses to alcohol. Alcohol Clin Exp Res 35:400-407 (2011).
  31. Vatsalya V, Issa JE, Hommer DW, Ramchandani VA. Pharmacodynamic effects of intravenous alcohol on hepatic and gonadal hormones: Influence of age and sex. Alcohol Clin Exp Res 36:207-213 (2012).
  32. Snell L, Ramchandani VA, Saba, L, Herion D, Heilig M, George D, Pridzun L, Helander A, Schwandt M, Phillips M, Hoffman P, Tabakoff B. The Biometric Measurement of Alcohol Consumption. Alcohol Clin Exp Res 36:332-341 (2012).
  33. Gilman JM, Smith AR, Ramchandani VA, Momenan R, Hommer DW. The effect of intravenous alcohol on the neural correlates of risky decision-making. Addiction Biology 17:465-478 (2012).
  34. Gilman JM, Ramchandani VA, Crouss T, Hommer DW. Subjective and neural responses to intravenous alcohol in young adults with light and heavy drinking patterns. Neuropsychopharmacology 37:467-477 (2012).
  35. Kalu N, Ramchandani VA, Marshall V, Scott D, Ferguson C, Cain G, Taylor R. Heritability of level of response and association with recent drinking history in non-alcohol dependent drinkers. Alcohol Clin Exp Res 36:1034-1041 (2012).
  36. Huang M-C, Schwandt ML, Ramchandani VA, George DT, Heilig M. Impact of multiple types of childhood trauma exposure on risk of psychiatric comorbidity among alcoholic inpatients. Alcohol Clin Exp Res 36:1099-1107 (2012).
  37. Schwandt ML, Heilig MA, Hommer DW, George DT, Ramchandani VA. Childhood trauma exposure and alcohol dependence severity in adulthood: mediation by emotional abuse severity and neuroticism. Alcohol Clin Exp Res 37:984-992 (2013).
  38. Leggio L, Schwandt ML, Oot EN, Dias AA, Ramchandani VA. Fasting-induced increase in plasma ghrelin is blunted by intravenous alcohol administration: A within-subject placebo-controlled study. Psychoneuroendocrinology 38:3085-3091 (2013).
  39. Marshall VJ, Ramchandani VA, Kalu N, Kwaygan J, Scott DM, Ferguson CL, Taylor RE. Evaluation of the influence of ADH polymorphisms on alcohol elimination rates measured using the alcohol clamp. Alcohol Clin Exp Res 38:51-59 (2014).
  40. Huang M-C, Schwandt ML, Chester J, Kirchhoff A, Kao C-F, Liang T, Tapocik J, Ramchandani VA, George DT, Hodgkinson C,  Goldman D, Heilig M. FKBP5 Moderates Alcohol Withdrawal Severity: Human Genetic Association and Functional Validation in Knockout Mice. Neuropsychopharmacology 39:2029-2038 (2014).
  41. Mitchell MC, Teigen EL, Ramchandani VA. Absorption and peak blood alcohol concentration after drinking beer, wine or spirits. Alcohol Clin Exp Res 38:1200-1204 (2014).
  42. Vatsalya V, Momenan R, Hommer DW, Ramchandani VA. Cardiac Reactivity during the ascending phase of Acute Intravenous Alcohol Exposure and Association with Subjective Perceptions of Intoxication in Social Drinkers. Alcohol Clin Exp Res 38:1247-1254 (2014).
  43. Kwako LE, Schwandt ML, Sells JR, Ramchandani VA, Hommer DW, George DT, Sinha R, Heilig M. Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes. Addict Biol, 20:733-746 (2014). Epub: doi: 10.1111/adb.12150.
  44. Strang NM, Claus ED, Ramchandani VA, Graff-Guerrero A, Boileau I, Hendershot CS. Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults. Psychopharmacology 232:733-744 (2014).
  45. Wallen GR, Brooks AT, Whiting B, Clark R, Krumlauf MC, Yang L, Schwandt ML, George DT, Ramchandani VA. The prevalence of sleep disturbance in alcoholics admitted for treatment: A target for chronic disease management. Fam Community Health 37:288-297 (2014).
  46. Spagnolo P, Ramchandani VA, Schwandt ML, Zhang L, Blaine S, Usala J, Diamond C, Phillips M, Momenan R, George DT, Heilig M,. Effects of naltrexone on neural and subjective response to alcohol in treatment-seeking alcohol dependent patients. Alcohol Clin Exp Res 38:3024-3032 (2014).
  47. Gilman JM, Smith AR, Bjork JM, Ramchandani VA, Momenan R, Hommer DW. Cumulative gains enhance striatal response to reward opportunities in alcohol-dependent patients. Addict Biol 20:580-593 (2015).  Epub: doi: 10.1111/adb.12147.
  48. Hendershot CS, Wardell JD, Strang NM, Markovich MS, Claus ED, Ramchandani VA. Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence. Exp Clin Psychopharmacol 23:147-158 (2015).
  49. Suchankova P, Yan J, Schwandt ML, Stangl BL, Caparelli EC, Momenan R, Jerlhag E, Engel JA, Hodgkinson CA, Egli M, Lopez MF, Becker HC, Goldman D, Heilig M, Ramchandani VA, Leggio L. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence. Transl Psychiatry 16;5:e583. doi: 10.1038/tp.2015.68 (2015).
  50. Vatsalya V, Gowin JL, Schwandt ML, Momenan R, Coe MA, Cooke ME, Hommer DW, Bartlett S, Heilig M, Ramchandani VA. Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers. Int J Neuropsychopharmacol (2015). Epub: doi: 10.1093/ijnp/pyv068. 
  51. Wardell JD, Ramchandani VA, Hendershot CS. A multilevel structural equation model of within- and between-person associations among subjective responses to alcohol, craving, and laboratory alcohol self-administration. J Abnorm Psychol 124: 1050-1063 (2015). Epub: doi: 10.1037/abn0000121.
  52. Hendershot CS, Claus ED, Ramchandani VA. Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults. Addict Biol 21:125-135 (2016). Epub: doi: 10.1111/adb.12165.
  53. Gowin JL, Vatsalya V, Westman JG, Schwandt ML, Bartlett S, Heilig M, Momenan R, Ramchandani VA. The effect of varenicline on the neural processing of fearful faces and the subjective effects of alcohol in heavy drinkers. Alcohol Clin Exp Res, 40: 979-987 (2016). Epub: doi: 10.1111/acer.13046.
  54. Hendershot CS, Wardell JD, McPhee MD, Ramchandani VA. A prospective study of genetic factors, alcohol response phenotypes, and heavy drinking in late adolescence. Addict Biol, (2016) Epub: doi: 10.1111/adb.12397.
  55. Sells JR, Waters AJ, Schwandt ML, Kwako LE, Heilig M, George DT, Ramchandani VA. Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences. Drug Alcohol Depend, 163: 242-246 (2016). Epub: doi: 10.1016/j.drugalcdep.2016.03.016.
  56. Vatsalya V, Pandey A, Schwandt ML, Cave MC, Barve SS, Ramchandani VA, McClain CJ. Safety assessment of liver injury with quetiapine fumarate XR management in very heavy drinking alcohol-dependent patients. Clin Drug Investig, 2016. Epub: 10.1007/s40261-016-0439-2.
  57. Vatsalya V, Barve SS, McClain CJ, Ramchandani VA. Elevated linoleic acid (a pro-inflammatory PUFA) and liver injury in a treatment naïve HIV-HCV co-infected alcohol dependent patient. J Biosci Med, 4: 23-27 (2016). Epub: doi: 10.4236/jbm.2016.47003.
  58. Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Hillard CJ, Heilig M. FAAH gene variation moderates stress response and symptom severity in patients with post-traumatic stress disorder and comorbid alcohol dependence. Alcohol Clin Exp Res, In press.
  59. Vatsalya V, Song M, Schwandt ML, Cave MC, Barve SS, George DT, Ramchandani VA, McClain CJ. Effects of sex, drinking history and omega-3 and omega-6 fatty acids dysregulation on the onset of liver injury in very heavy drinking alcohol dependent patients. Alcohol Clin Exp Res, In press.

Reviews and Book Chapters:

  1. Ramchandani VA, Bosron WF, Li T-K. Research advances in ethanol metabolism. Pathologie Biologie 49:676-682 (2001).
  2. Ramchandani VA. Genetic aspects of alcohol metabolism. In Alcohol in disease: Nutrient interactions and dietary intake (Watson RR and Preedy VR, ed). Boca Raton, CRC Press: 187-199 (2004).
  3. Ramchandani VA, O’Connor S. Studying alcohol elimination using the alcohol clamp method. Alcohol Research and Health 29:286-290 (2006).
  4. Heilig M, Thorsell A, Sommer WH, Hansson AC, Ramchandani VA, George DT, Hommer D, Barr CS. Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues. Neurosci Biobehav Rev 35:334-344 (2010).
  5. Hendler RA, Ramchandani VA, Gilman J, Hommer DW. Stimulant and sedative effects of alcohol. Curr Top Behav Neurosci 13:489-509 (2013).
  6. Zimmermann US, O’Connor S, Ramchandani VA. Modeling alcohol self-administration in the human laboratory. Curr Top Behav Neurosci 13:315-353 (2013).
  7. Ramchandani VA. Genetic aspects of alcohol metabolism. In Alcohol, Nutrition and Health Consequences (Watson RR, Preedy VR, Zibadi S, ed). New York, Humana Press:15-25 (2013).
  8. Ramchandani VA, Slattum PW, Patkar AA, Wu L-T, Lee JC, Mohanty M, Coe M, Li T-K. Psychopharmacology and the consequences of alcohol and drug interactions. In: Substance Use and Older People (Crome I, Wu L-T, Rao T, Crome P, ed). United Kingdom, Wiley Blackwell:149-170 (2015).

NIH Research and Training Opportunities