Overview of the Lab
What we do
The Clinical NeuroImaging Research Core (CNIRC) serves two functions: Conducting independent addiction neuroimaging and psychophysiological studies and providing expertise in these areas, through collaborations and support to clinical investigators.
We are looking to add a post-doctoral researcher to our team. Learn about the position and how to apply.
Research interests include:
- Investigate the neural correlates of cognition, emotions, decision making, motivation, impulsive and compulsive behaviors, and their association with alcohol use disorder.
- Neurocircuitries associated with stages of alcohol use and misuse.
- Examine the dynamic relationship between brain structure and function and alcohol use disorders.
- Utilize imaging phenotypes to establish efficacy of experimental treatments and therapies.
- Utilize imaging biomarkers to determine treatment choice and predict treatment outcome and relapse.
- Utilize novel approaches to further refine alcohol use disorder subtypes and their treatments by combining imaging phenotypes and psychophysiological data.
Clinical collaborations and support include:
- Enhance imaging capabilities
- Prototype paradigms and methodologies
- Assist PI’s in protocol development with imaging components, including, for example advice on practicality, power analysis, etc.
- Conduct imaging components of the studies including:
- Implement imaging paradigms
- Supervise/conduct scanning sessions
- Perform image processing
- Perform imaging analyses
- Present imaging results
- Develop and provide imaging informatics
- Standardize and track imaging data
- Provide imaging study database
- Provide recommendations to the OSD and OCD in prioritization and advance planning of the studies involving neuroimaging.
- Provide Intramural and NIH Clinical Elective Program trainings in imaging
14-AA-0094 Neural Substrate of Approach Avoidance in Alcoholism
14-AA-0066 Behavioral and Functional MRI Task Development, Implementation, and Testing
14-AA-0080 Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
15-AA-0203 Cross-Sectional and Longitudinal Study of Structural Imaging
18-AA-0098 Investigating a Response Modulation Hypothesis of Socioemotional Processing associated with Alcohol Use Disorder
Samantha J. Fede, Erica N. Grodin, Sarah J. Dean, Nancy Diazgranados, and Reza Momenan (2019), Resting State Connectivity Best Predicts Alcohol Use Severity in Moderate to Heavy Alcohol Users, NeuroImage: Clinical, Mar 19;22:101782. doi: 10.1016/j.nicl.2019.101782 PubMed
Erica Grodin, Lauren Sussman, Kelsey Sundby, Grace Brennan, Nancy Diazgranados, Markus Heilig, Reza Momenan, Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3(12):1022-1031 Link
Xi Zhu, Xiaofei Du, Mike Kerich, Falk W. Lohoff, Reza Momenan (2018), Random Forest Based Classification of Alcohol Dependence Patients and Healthy Controls Using Resting State MRI, Neuroscience Letters, 676, 27-33 Link
Carlos R. Cortes, Erica N. Grodin, Claire L. Mann, Karan Mathur, Michael Kerich, Xi Zhu, Melanie Schwandt, Nancy Diazgranados, David T. George, Reza Momenan, Markus Heilig (2018), Insula Sensitivity to Unfairness in Alcohol Use Disorder, Alcohol and Alcoholism, doi: 10.1093/alcalc/agx115. PubMed
Xi Zhu, Xiaofei Du, Mike Kerich, Falk W. Lohoff, Reza Momenan (2018), Random Forest Based Classification of Alcohol Dependence Patients and Healthy Controls Using Resting State MRI, Neuroscience Letters, 676 (2018) 27-33. PubMed
Erica N. Grodin, Carlos R. Cortes, Primvera Spagnolo, Reza Momenan (2017), Structural Deficits in Salience Network Regions Are Associated with Increased Impulsivity and Compulsivity in Alcohol Dependence, Drug and Alcohol Dependence, 2017 Oct 1;179:100-108. PubMed
Laura E. Kwako, Reza Momenan, Erica N. Grodin, Raye Z. Litten, David Goldman (2017); Addictions Neuroclinical Assessment: A Reverse Translational Approach, Journal of NeuroPsychoPharmacology, Volume 122, 1 August 2017, Pages 254-264. PubMed
Vladimir V. Senatorov, Claire L. Mann, Melanie L. Schwandt, Markus Heilig, Daniel W. Hommer, Reza Momenan, Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons, Brain, 2015 Jan;138(Pt 1):69-79. PubMed
Durkee C, Sarlls J, Hommer D, Momenan R, White matter microstructure alterations: a study of alcoholics with and without post-traumatic stress disorder, PLoS One (2013) Volume 8, Issue 11, e80952, 1-10. PubMed
Leah M. Mayo, Diana Fraser, Emma Childs, Reza Momenan, Daniel Hommer, Harriet de Wit, Markus Heilig, Conditioned preference to a methamphetamine-associated contextual cue in humans, Journal of Neuropsychopharmocology (2013) 38, 921–29. PubMed
Grodin E., Lin H., Hommer, D.W., Durkee, C.A., Momenan R., Deficits in cortical, diencephalic and midbrain gray matter in alcoholism measured by VBM: Effects of co-morbid substance abuse, NeuroImage: Clinical (2013) 2: 469-76. PubMed
Momenan, R., Steckler L.E., Saad Z., van Rafelghem S., Kerich, M., and Hommer, D.W., Effects of alcohol dependence on cortical thickness (2012), Psychaiatry Research: Neuroimaging, Volume 204, Issues 2–3, 30 November (2012), Pages 101–111. PubMed
Bjork JM, Chen G, Smith AR, Hommer DW: Incentive-elicited mesolimbic activation in adolescents with externalizing disorders. Journal of Child Psychology & Psychiatry. 2010 Jul 11;51(7):827-37. PubMed
Gilman JM, Davis MB, Hommer DW: Greater activation in left hemisphere language–related regions during simple judgment tasks among substance-dependent patients in treatment for alcoholism. Alcoholism: Clinical and Experimental Research. 2010 Feb;34(2):331–41. PubMed
Bjork JM, Momenan R, and Hommer DW: Delay discounting correlates with proportional lateral frontal cortex volumes. Biological Psychiatry. 2009 Apr 15;65(8):710-3. PubMed
Bjork JM, Smith AR, Hommer DW: Striatal sensitivity to reward deliveries and omissions in substance dependent patients, NeuroImage. 2008 Oct 1;42(4):1609-21. PubMed
Gilman JM, Hommer DW. Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients. Addiction Biology. 2008 Sep;13(3-4):423-34. PubMed
Bjork JM, Knutson B, Hommer DW: Incentive-elicited striatal activation in adolescent children of alcoholics. Addiction. 2008 Aug;103(8):1308-19. PubMed
Bjork JM, Momenan R, Smith A, Hommer DW. Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients. Alcohol and Drug Dependence. 2008 May 1;95(1-2):115-28. PubMed
Gilman JM, Ramchandani VA , Davis MB , Bjork JM, Hommer DW. Why we like to drink: An fMRI Study of the Rewarding and Anxiolytic Effects of Alcohol. Journal of Neuroscience. 2008 Apr 30;28(18):4583-91. PubMed
George DT, Gilman J, Hersh J, Thorsell A, Herion D, Geyer C, Peng X, Kielbasa W, Rawlings R, Brandt J, Gehlert DR, Tauscher JT, Hunt SP, Hommer D, Heilig M. Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science. 2008 Mar 14;319(5869):1536-9. PubMed
Gilman JM, Bjork JM, Hommer DW. Parental alcohol use and brain volumes in early- and late-onset alcoholics. Biological Psychiatry. 2007 Sep 15;62(6):607-15. PubMed
Salloum JB, Ramchandani VA, Bodurka J, Rawlings R, Momenan R, George D, Hommer DW. Blunted rostral anterior cingulate response during a simplified decoding task of negative facial expressions in alcoholic patients. Alcoholism: Clinical and Experimental Research. 2007 Sep;31(9):1490-504. PubMed
Schottenbauer MA, Hommer D, Weingartner H. Memory deficits among alcoholics: Performance on a selective reminding task. Aging, Neuropsychology, and Cognition. 2007 Sep;14(5):505-516. PubMed
Bjork JM, Smith A, Danube C, Hommer DW. Developmental differences in posterior mesofrontal cortex recruitment by risky rewards. Journal of Neuroscience. 2007 May 2;27(18):4839-49. PubMed
Schottenbauer MA, Momenan R, Kerich M, Hommer DW. Relationships among aging, IQ, and intracranial volume in alcoholics and control subjects. Neuropsychology. 2007 May;21(3):337-45. PubMed
Bjork JM, Hommer DW. Anticipating instrumentally obtained and passively-received rewards: A factorial fMRI investigation. Behavioural Brain Research. 2007 Feb 12;177(1):165-70. PubMed
Brown AK, George DT, Fujita M, Liow J, Ghose S, Sangare J, Hommer DW, Innis RB. PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. Alcoholism: Clinical and Experimental Research. 2007 Jan;31(1):28-32. PubMed
Rio DE, Rawlings RR, Woltz LA, Salloum JB, Hommer DW. Single subject image analysis using complex general linear model - An application to functional magnetic imaging with multiple inputs. Computer Methods and Programs in Biomedicine. 2006 Apr;82(1):10-9. PubMed
Bjork JM, Hommer DW, Grant SJ, Danube C. Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. Alcohol. 2004 Oct-Nov;34(2-3):133-50. PubMed
Knutson B, Bjork JM, Fong GW, Hommer D, Mattay VS, Weinberger DR. Amphetamine modulates human incentive processing. Neuron. 2004 Jul 22;43(2):261-9. PubMed
Momenan R, Rawlings R, Fong G, Knutson B, Hommer D. Voxel-based homogeneity probability maps of gray matter in groups: assessing the reliability of functional effects. Neuroimage. 2004 Mar;21(3):965-72. PubMed
Bjork JM, Knutson B, Fong GW, Caggiano DM, Bennett SM, Hommer DW. Incentive-elicited brain activation in adolescents: similarities and differences from young adults. J Neurosci. 2004 Feb;24(8):1793-802. PubMed
Bjork JM, Grant SJ, Hommer DW. Cross-sectional volumetric analysis of brain atrophy in alcohol dependence: effects of drinking history and comorbid substance use disorder. Am J Psychiatry. 2003 Nov;160(11):2038-45. PubMed
REVIEWS AND BOOK CHAPTERS
Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Le, AD, Hipskind, PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh, J, Tauscher JT, Hunt SP, Hommer, D, Heilig M: Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol. 2009 Nov;43:491-8. PubMed
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